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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Cranberry interacts with dietary macronutrients to promote healthy aging in drosophila
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Cranberry interacts with dietary macronutrients to promote healthy aging in drosophila

机译：蔓越莓与膳食中的大量营养素相互作用，促进果蝇的健康衰老

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摘要

Botanicals possess numerous bioactivities, and some promote healthy aging. Dietary macronutrients are major determinants of life span. The interaction between botanicals and macronutrients that modulates life span is not well understood. Here, we investigated the effect of a cranberry-containing botanical on life span and the influence of macronutrients on the longevity-related effect of cranberry in Drosophila. Flies were supplemented with cranberry on three dietary conditions: standard, high sugar-low protein, and low sugar-high protein diets. We found that cranberry slightly extended life span in males fed with the low sugar-high protein diet but not with other diets. Cranberry extended life span in females fed with the standard diet and more prominently the high sugar-low protein diet but not with the low sugar-high protein diet. Life-span extension was associated with increased reproduction and higher expression of oxidative stress and heat shock response genes. Moreover, cranberry improved survival of sod1 knockdown and dfoxo mutant flies but did not increase wild-type fly's resistance to acute oxidative stress. Cranberry slightly extended life span in flies fed with a high-fat diet. These findings suggest that cranberry promotes healthy aging by increasing stress responsiveness. Our study reveals an interaction of cranberry with dietary macronutrients and stresses the importance of considering diet composition in designing interventions for promoting healthy aging.
机译：植物药具有多种生物活性，其中一些促进健康衰老。饮食中的大量营养素是寿命的主要决定因素。植物性物质和大量营养素之间的相互作用会影响生命周期，人们对此了解甚少。在这里，我们研究了在果蝇中含蔓越莓的植物药对寿命的影响以及常量营养素对蔓越莓的寿命相关影响的影响。在三种饮食条件下，果蝇均添加了蔓越莓：标准饮食，高糖低蛋白饮食和低糖高蛋白饮食。我们发现，低糖高蛋白饮食喂养的男性，蔓越莓的寿命略有延长，而其他饮食饮食则没有。蔓越莓延长了使用标准饮食，高糖低蛋白饮食但不摄取低糖高蛋白饮食的女性的寿命。寿命的延长与氧化应激和热休克反应基因的繁殖增加和更高的表达有关。此外，酸果蔓提高了sod1敲除和dfoxo突变果蝇的存活率，但并未增加野生型果蝇对急性氧化应激的抗性。在以高脂饮食喂养的果蝇中，蔓越莓的寿命略有延长。这些发现表明，蔓越莓通过增加压力反应性来促进健康的衰老。我们的研究揭示了蔓越莓与饮食中大量营养素的相互作用，并强调了在设计干预措施以促进健康衰老时考虑饮食组成的重要性。

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