...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Circulating acute phase mediators and skeletal muscle performance in hospitalized geriatric patients.
【24h】

Circulating acute phase mediators and skeletal muscle performance in hospitalized geriatric patients.

机译：住院老年患者的循环急性期介质和骨骼肌表现。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: There is growing evidence for the significant involvement of inflammatory processes in the development of muscle wasting in old age. Therefore, any disease accompanied by inflammation can be threatening to the muscle function in geriatric patients. METHODS: Sixty-three hospitalized geriatric patients (42 female, 21 male; mean age 84.2 +/- 5.7 years) were monitored weekly for muscle function (grip strength, fatigue resistance, shoulder extension strength, and hip extension strength) and for concentration of circulating C-reactive protein (CRP), fibrinogen, interleukin 6 (IL-6), and tumor necrosis factor-alpha alpha (TNF-alpha). RESULTS: On the basis of circulating CRP and fibrinogen concentrations, 42 patients were categorized on admission as inflammatory and 21 as noninflammatory. Inflammatory patients presented significantly weaker grip strength, shoulder extension strength, and a worse fatigue resistance than did noninflammatory patients. These muscle functions were negatively correlated with the concentrations of circulating CRP and IL-6, but not with fibrinogen or TNF-alpha. In noninflammatory patients, the fatigue resistance improved significantly during the first week of hospitalization. In patients admitted with inflammation, no improvement of muscle function was observed. Patients who remained inflammatory for 2 weeks or more presented a significant worsening of fatigue resistance. CONCLUSIONS: Geriatric hospitalized patients presenting with inflammation show significantly worse muscle functions, which do not improve during hospitalization despite adequate treatment of the primary disease. Reduced strength and fatigue resistance are significantly related to the concentration of circulating CRP and IL-6. Standard treatment of the underlying illness and classic physical therapy are not sufficient to normalize the skeletal muscle strength and fatigue resistance in these hospitalized patients.
机译：背景：越来越多的证据表明，炎症过程与老年肌肉消瘦的发展密切相关。因此，任何伴随炎症的疾病都可能威胁老年患者的肌肉功能。方法：每周监测63例住院的老年患者（42例女性，21例男性;平均年龄84.2 +/- 5.7岁），监测其肌肉功能（握力，耐疲劳性，肩部伸展力量和髋部伸展力量）并监测其浓度。循环C反应蛋白（CRP），纤维蛋白原，白介素6（IL-6）和肿瘤坏死因子-α（TNF-alpha）。结果：根据循环CRP和纤维蛋白原浓度，入院时将42例患者归为炎性，将21例归为非炎性。与非炎性患者相比，炎性患者的握力，肩伸强度和耐疲劳性明显弱。这些肌肉功能与循环CRP和IL-6的浓度呈负相关，但与纤维蛋白原或TNF-α没有负相关。在非炎性患者中，住院第一周的抗疲劳性明显改善。在患有炎症的患者中，未观察到肌肉功能的改善。炎症持续2周或更长时间的患者表现出明显的疲劳抵抗力恶化。结论：有炎症的老年住院患者表现出明显的肌肉功能恶化，尽管对原发疾病进行了适当的治疗，但在住院期间并没有改善。降低的强度和抗疲劳性与循环CRP和IL-6的浓度显着相关。潜在疾病的标准治疗和经典的物理疗法不足以使这些住院患者的骨骼肌力量和疲劳抵抗力正常化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号