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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Differences in the association between apolipoprotein E genotype and mortality across populations.
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Differences in the association between apolipoprotein E genotype and mortality across populations.

机译：人群中载脂蛋白E基因型与死亡率之间的关联差异。

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BACKGROUND: The gene for apolipoprotein-E (APOE) has three common alleles (epsilon2, epsilon3, and epsilon4) that have been shown to be associated with differences in the risk of death in persons older than 60 years in European populations. However, previous research suggests that they may not be associated with mortality in African Americans, and the evidence in Asians is mixed. It is now possible to examine the effects of these genotypes on mortality in African American, Chinese, Japanese, and Korean populations. METHODS: The analysis is based on two types of published data: genotype by age and mortality by genotype. Demographic synthesis uses a multistate model to combine data from these case-control and cohort studies to provide maximum likelihood estimates of the relative risks of death. RESULTS: In general, the APOE epsilon2 allele is associated with 5%-10% lower mortality than the epsilon3/3 genotype. The epsilon4/4 allele is generally associated with a moderately high relative risk of death. The epsilon3/4 genotype is associated with 22% excess risk in Europeans and U.S. whites and with about 35% in Chinese. However, there is no evidence of excess risk with epsilon3/4 among African Americans and little excess risk among Japanese and Koreans. The relationship between genotype and mortality is consistent within these ethnic groups. For example, the estimates of R(3/4) for Japanese in Japan and Hawaii are both low, and the estimates for Chinese in Taiwan and Shanghai are relatively high. CONCLUSIONS:. The relationship between APOE genotype and mortality differs across population groups but shows little evidence of variation within groups.
机译：背景：载脂蛋白E（APOE）基因具有三个常见的等位基因（epsilon2，epsilon3和epsilon4），这些等位基因与欧洲人群中60岁以上人群的死亡风险差异相关。但是，先前的研究表明，他们可能与非裔美国人的死亡率无关，而亚洲人的证据则好坏参半。现在可以检查这些基因型对非洲裔美国人，中国人，日本人和韩国人的死亡率的影响。方法：该分析基于两种类型的已公开数据：按年龄划分的基因型和按基因型划分的死亡率。人口统计学综合使用多状态模型来合并来自这些病例对照研究和队列研究的数据，以提供死亡相对风险的最大似然估计。结果：一般而言，APOE epsilon2等位基因的死亡率比epsilon3 / 3基因型低5％-10％。 epsilon4 / 4等位基因通常与中等较高的相对死亡风险相关。 epsilon3 / 4基因型与欧洲人和美国白人中22％的过高风险以及中国人中约35％的过高风险相关。但是，没有证据表明非裔美国人会出现epsilon3 / 4的过度风险，而日本人和韩国人几乎没有过度风险。在这些种族中，基因型与死亡率之间的关系是一致的。例如，日本和夏威夷的日本人的R（3/4）估计值都较低，而台湾和上海的中国人的估计值相对较高。结论： APOE基因型与死亡率之间的关系在不同人群之间有所不同，但几乎没有证据表明各组之间存在差异。

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