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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Serum anticholinergic activity and motor performance in elderly persons.
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Serum anticholinergic activity and motor performance in elderly persons.

机译：老年人的血清抗胆碱能活动和运动表现。

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摘要

BACKGROUND: Medications prescribed to elderly persons often have an anticholinergic effect, as do many commonly used over-the-counter drugs. Anticholinergic medications are known to produce psychomotor slowing, especially in older persons. METHODS: The present study examined whether the cumulative anticholinergic load present in the serum of community volunteers was associated with decrements on tests of psychomotor performance (gait speed and simple manual response time) known to predict falls in elderly persons. RESULTS: Serum anticholinergic activity (SAA) was relatively low in this group; however, an elevated SAA was associated with a significant slowing in both gait speed and simple response time. CONCLUSION: Cumulative anticholinergic burden may be one of the factors contributing to an increased risk of falls in the older population.
机译：背景：与许多常用的非处方药一样，开给老年人的药物通常具有抗胆碱作用。已知抗胆碱能药物会导致精神运动减慢，尤其是在老年人中。方法：本研究调查了社区志愿者血清中累积的抗胆碱能负荷是否与已知可预测老年人跌倒的心理运动表现测试（步态速度和简单的手动反应时间）下降有关。结果：该组的血清抗胆碱能活性（SAA）相对较低。然而，升高的SAA与步态速度和简单反应时间的显着降低有关。结论：累积的抗胆碱能负担可能是导致老年人口跌倒风险增加的因素之一。

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