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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Variegated expression of Hsp22 transgenic reporters indicates cell-specific patterns of aging in Drosophila oenocytes
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Variegated expression of Hsp22 transgenic reporters indicates cell-specific patterns of aging in Drosophila oenocytes

机译：Hsp22转基因报告基因的杂色表达表明果蝇单核细胞衰老的细胞特异性模式

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摘要

The cytoplasmic chaperone gene Hsp70 and the mitochondrial chaperone gene Hsp22 are upregulated during normal aging in Drosophila in tissue-general patterns. In addition, Hsp22 reporters are dramatically upregulated during aging in a subset of the oenocytes (liver-like cells). Hsp22 reporter expression varied dramatically between individual oenocytes and between groups of oenocytes located in adjacent body segments, and was negatively correlated with accumulation of age pigment, indicating cell-specific and cell-lineage-specific patterns of oenocyte aging. Conditional transgenic systems were used to express 88 transgenes to search for trans-regulators of the Hsp70 and Hsp22 reporters during aging. The wingless gene increased tissue-general upregulation of both Hsp70 and Hsp22 reporters. In contrast, the mitochondrial genes MnSOD and Hsp22 increased expression of Hsp22 reporters in the oenocytes and decreased accumulation of age pigment in these cells. The data suggest that cell-specific and cell lineage-specific patterns of mitochondrial malfunction contribute to oenocyte aging.
机译：在果蝇的正常衰老过程中，细胞质伴侣基因Hsp70和线粒体伴侣基因Hsp22以组织一般模式上调。另外，在衰老过程中，一部分细胞（肝样细胞）中的Hsp22报告基因被显着上调。 Hsp22报告基因表达在单个的卵母细胞之间以及位于相邻身体节段的各组卵母细胞之间显着变化，并且与年龄色素的积累呈负相关，表明细胞特异性和细胞谱系特异性的卵母细胞衰老模式。有条件的转基因系统用于表达88个转基因，以寻找衰老过程中Hsp70和Hsp22报告基因的反式调节子。无翼基因增加了Hsp70和Hsp22报告基因的组织总体上调。相比之下，线粒体基因MnSOD和Hsp22增加了Hsp22报告基因在卵母细胞中的表达，并减少了这些细胞中年龄色素的积累。数据表明，线粒体功能异常的细胞特异性和细胞谱系特异性模式促进了成骨细胞的衰老。

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