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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Change in 25-hydroxyvitamin D and physical performance in older adults.
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Change in 25-hydroxyvitamin D and physical performance in older adults.

机译：老年人中25-羟基维生素D和身体机能的变化。

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BACKGROUND: Vitamin D deficiency is common among older adults and is associated with poor physical performance; however, studies examining longitudinal changes in 25-hydroxyvitamin D (25[OH]D) and physical performance are lacking. We examined the association between 25(OH)D and physical performance over 12 months in older adults participating in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P), a multicenter physical activity intervention trial. METHODS: Plasma 25(OH)D and physical performance, assessed by the short physical performance battery (SPPB) and 400-m walk test, were measured at baseline, 6-month, and 12-month follow-up in community-dwelling adults aged 70-89 years at risk for disability (n = 368). Mixed models were used to examine the association between 25(OH)D and physical performance adjusting for demographics, intervention group, season, body mass index, and physical activity. RESULTS: One half of the participants were vitamin D deficient (25[OH]D < 20 ng/mL) at baseline. In cross-sectional analyses, vitamin D deficiency was associated with lower SPPB scores and slower 400-m walk speeds (mean difference [SE]: 0.35 [0.16], p = .03 and 0.04 [0.02] m/s, p = .01, respectively). Although baseline 25(OH)D status was not significantly associated with change in physical performance over 12 months, individuals who were vitamin D deficient at baseline but no longer deficient at follow-up had significant improvements in SPPB scores (mean difference [SE]: 0.55 [0.22], p = .01) compared with those whose 25(OH)D status remained the same. CONCLUSION: Increases in 25(OH)D to greater than or equal to 20 ng/mL were associated with clinically significant improvements in physical performance among older adults.
机译：背景：维生素D缺乏症在老年人中很常见，并与身体机能不佳有关;但是，缺乏研究25-羟基维生素D（25 [OH] D）的纵向变化和物理性能的研究。我们研究了参加多中心体育锻炼干预试验的生活方式干预和老年人独立性飞行员（LIFE-P）的老年人在过去12个月内25（OH）D与身体机能之间的关系。方法：在社区居住的成年人中，在基线，6个月和12个月的随访中，通过短期体能电池（SPPB）和400 m步行测试评估了血浆25（OH）D和体能。 70-89岁有残疾风险（n = 368）。混合模型用于检查25（OH）D与身体机能调整之间的关联，以调整人口统计学，干预组，季节，体重指数和身体活动。结果：一半的参与者在基线时维生素D缺乏（25 [OH] D <20 ng / mL）。在横断面分析中，维生素D缺乏症与较低的SPPB评分和较慢的400-m步行速度有关（平均差[SE]：0.35 [0.16]，p = .03和0.04 [0.02] m / s，p =）。分别为01）。尽管基线25（OH）D状态在12个月内与身体机能的变化并没有显着相关，但是基线时维生素D缺乏但随访中不再缺乏的人的SPPB评分有显着改善（平均值差异[SE]： 0.55 [0.22]，p = 0.01）与25（OH）D状态保持不变的那些相比。结论：25（OH）D升高至大于或等于20 ng / mL与老年人身体机能的临床显着改善有关。

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