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首页> 外文期刊>The Journal of rheumatology >Clinical relevance of MEFV gene mutations in Japanese patients with unexplained fever
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Clinical relevance of MEFV gene mutations in Japanese patients with unexplained fever

机译：日本不明原因发热患者MEFV基因突变的临床意义

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To the Editor:At the beginning of 2007, we investigated the frequencies of MEFV gene mutations in Japanese patients with unexplained fever or undifferentiated arthritis to determine their role in phenotypical features of familial Mediterranean fever (FMF)-related diseases. Patients were asked to complete a questionnaire concerning fever, recurrent typical attacks of FMF, including peritonitis, pleuritis, and arthritis, and transient inflammatory response. On the basis of the Tel-Hashomer criteria1, we divided the study subjects into 3 groups, as follows: Group 1, typical FMF (presence of 1 or more major criteria independent of the presence of minor criteria); Group 2, probable FMF (absence of major criteria and 2 or more minor criteria); Group 3, unlikely (not belonging to either Group 1 or 2). Patients who had previously been diagnosed with typical FMF were not included. All patients were first enrolled as having unexplained fever, and finally diagnosed as FMF based on clinical evidence. We stress that the overall survey for the recent clinical manifestations, including the response to colchicine, was not complete in a few patients.
机译：致编者：2007年初，我们调查了日本原因不明的发热或未分化的关节炎患者的MEFV基因突变的频率，以确定它们在家族性地中海热（FMF）相关疾病的表型特征中的作用。要求患者填写一份有关发烧，FMF复发性典型发作（包括腹膜炎，胸膜炎和关节炎）和短暂性炎症反应的问卷。根据Tel-Hashomer标准1，我们将研究对象分为3组，如下：第1组，典型FMF（存在1个或多个主要标准，独立于次要标准）;第2组，可能的FMF（不存在主要标准和2个或更多次要标准）;组3，不太可能（不属于组1或2）。以前诊断为典型FMF的患者不包括在内。所有患者首先入选原因不明的发热，最后根据临床证据诊断为FMF。我们强调，在少数患者中，尚未完成对近期临床表现（包括对秋水仙碱的反应）的总体调查。

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