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首页> 外文期刊>The Lichenologist >Prion protein degradation by lichens of the genus Cladonia.
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Prion protein degradation by lichens of the genus Cladonia.

机译：lad草属的地衣降解蛋白。

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摘要

It has recently been discovered that lichens contain a serine protease capable of degrading the pathogenic prion protein, the etiological agent of prion diseases such as sheep scrapie and cervid chronic wasting disease. Limited methods are available to degrade or inactivate prion disease agents, especially in the environment, and lichens or their serine protease could prove important for management of these diseases. Scant information is available regarding the presence or absence of the protease responsible for degrading prion protein (PrP) in lichen species and, in this study, we tested the hypothesis that PrP degradation activity in lichens is phylogenetically-based by testing 44 species of Cladonia lichens, a genus for which a significant portion of the phylogeny is well established. We categorized PrP degradation activity among the 44 species (high, moderate, low or none) and found that activity in Cladonia species did not correspond with phylogenetic position of the species. Degradation of PrP did correspond, however, with three classical taxonomic characters within the genus: species with brown apothecia, no usnic acid, and the presence of a cortex. Of the 44 species studied, 18 (41%) had either high or moderate PrP degradation activity, suggesting the protease may be frequent in this genus of lichens.Digital Object Identifier http://dx.doi.org/10.1017/S0024282912000102
机译：最近发现，地衣含有一种能够降解致病性pr病毒蛋白的丝氨酸蛋白酶，,病毒蛋白是诸如绵羊瘙痒病和慢性萎缩性疾病之类的cer病毒疾病的病原体。有限的方法可用于降解或灭活病毒病原，尤其是在环境中，并且地衣或其丝氨酸蛋白酶可能对控制这些疾病具有重要意义。关于地衣物种中负责降解responsible病毒蛋白（PrP）的蛋白酶的存在或缺乏的信息很少，在这项研究中，我们通过测试44种Cladonia地衣物种，以系统发育为基础验证了PrP降解活性基于系统发育的假设。 ，其系统发育的重要部分已建立的属。我们对44种物种（高，中，低或无）中的PrP降解活性进行了分类，并发现了Cladonia物种中的活性与该物种的系统发育位置不符。但是，PrP的降解确实与该属中的三个经典分类学特征相对应：具有棕色紫杉醇，无松萝酸和存在皮质的物种。在研究的44个物种中，有18个（41％）具有高或中等的PrP降解活性，表明该地衣属中该蛋白酶可能是常见的。Digital Object Identifier http://dx.doi.org/10.1017/S0024282912000102

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