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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Cervical metastasis of germ cell tumors: evaluation, management, complications, and outcomes.
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Cervical metastasis of germ cell tumors: evaluation, management, complications, and outcomes.

机译：生殖细胞肿瘤的宫颈转移：评估，处理，并发症和结局。

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OBJECTIVES/HYPOTHESIS: Head and neck surgeons can be involved in the management of germ cell tumor (GCT) metastatic to the neck from initial diagnosis through postchemotherapy management of residual neck masses. This article reports on 34 consecutive patients with GCT metastatic to the neck. STUDY DESIGN: Retrospective chart review. METHODS: A single-institution retrospective chart review of 34 consecutive patients with GCT metastatic to the neck who underwent postchemotherapy neck surgery between 1991 and 2009 was performed. RESULTS: Seventy-four percent of patients had a neck mass at initial diagnosis, with 50% of patients having a neck mass as the presenting symptom leading to a diagnosis of GCT. Of the 37 neck procedures, positive nodes were found in 22. No significant relationship between preoperative tumor markers and neck pathology (P = .35) was identified. No patients had neck recurrence. No patients had permanent nerve injury or chyle leak. As a secondary end point, survival analysis related to cervical pathology showed that viable tumor in the neck predicted disease-specific survival (P = .01). Five- and 10-year disease-specific survival was 82.3% (median, 52-month follow-up). CONCLUSIONS: Operative management for patients with metastatic GCT to the neck can achieve long-term durable cervical control with limited complications.
机译：目的/假设：头颈外科医师可参与从最初诊断到残余颈部肿块的化学治疗后的转移到颈部的生殖细胞肿瘤（GCT）的管理。本文报道了34例连续转移至颈部的GCT患者。研究设计：回顾性图表审查。方法：对1991年至2009年间接受化疗后颈部手术的34例连续转移至颈部的GCT患者进行了单机构回顾性图表回顾。结果：74％的患者在初次诊断时出现颈部肿块，其中50％的患者以颈部肿块为症状，导致诊断为GCT。在37例颈部手术中，有22例发现淋巴结阳性。术前肿瘤标志物与颈部病理之间无显着相关性（P = .35）。没有患者有颈部复发。没有患者出现永久性神经损伤或乳糜漏。作为次要终点，与宫颈病理相关的生存分析表明，颈部存活的肿瘤可预测特定疾病的生存率（P = 0.01）。 5年和10年疾病特异性生存率为82.3％（中位数，为期52个月的随访）。结论：颈部转移性GCT患者的手术治疗可实现长期持久的宫颈控制，并发症少。

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