Distribution of respiratory mucin proteins in human nasal mucosa.

Groneberg DA; Peiser C; Dinh QT; Matthias J; Eynott PR; Heppt W; Carlstedt I; Witt C; Fischer A; Chung KF

首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Distribution of respiratory mucin proteins in human nasal mucosa.

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Distribution of respiratory mucin proteins in human nasal mucosa.

机译：呼吸黏蛋白蛋白在人鼻黏膜中的分布。

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OBJECTIVES/HYPOTHESIS: The upper respiratory tract is involved in many acute and chronic respiratory tract diseases that present with the symptom of mucus hypersecretion. Mucin genes that encode for the backbone of glycoproteins contribute to the viscoelastic property of airway mucus. We examined the cellular expression and distribution of two major respiratory mucus-forming glycoproteins, MUC5AC and MUC5B, in normal human nasal tissues. METHODS: Immunohistochemical analysis using polyclonal antibodies against the mucins MUC5AC and MUC5B was performed in normal human nasal tissues. RESULTS: An abundant staining of submucosal mucus gland and epithelial goblet cells for MUC5B was found. Immunohistochemical analysis of MUC5AC showed staining of surface epithelium goblet cells, whereas there was no staining of glandular cells. Comparison of the expression to lower airways revealed a similar pattern of expression of both mucins. CONCLUSIONS: The data in the present study demonstrated the localization of thetwo major respiratory mucin proteins in human nasal mucosa with a similar distribution of expression of MUC5AC and MUC5B in normal upper and lower airways. Mucin protein expression parallels that of mucin messenger RNA expression.

机译：目的/假设：上呼吸道与许多急，慢性呼吸道疾病有关，这些疾病表现为粘液分泌过多的症状。编码糖蛋白骨架的粘蛋白基因有助于气道粘液的粘弹性。我们检查了正常人鼻组织中两种主要的呼吸粘液形成糖蛋白MUC5AC和MUC5B的细胞表达和分布。方法：在正常人鼻组织中使用针对粘蛋白MUC5AC和MUC5B的多克隆抗体进行免疫组织化学分析。结果：发现MUC5B在粘膜下粘液腺和上皮杯状细胞中有大量染色。 MUC5AC的免疫组织化学分析显示表面上皮杯状细胞染色，而腺细胞没有染色。与下呼吸道的表达比较显示两种粘蛋白的表达模式相似。结论：本研究的数据证明了两种主要的呼吸粘蛋白蛋白在人鼻粘膜中的定位，在正常的上，下呼吸道中MUC5AC和MUC5B的表达分布相似。粘蛋白蛋白表达与粘蛋白信使RNA表达相似。

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《The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery ..》 |2003年第3期|共5页
作者
Groneberg DA; Peiser C; Dinh QT; Matthias J; Eynott PR; Heppt W; Carlstedt I; Witt C; Fischer A; Chung KF;
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正文语种 eng
中图分类耳鼻咽喉科学;
关键词
Mucins; Nasal Mucosa; Respiratory Tract Infections; Interleukin-1; Muc5AC protein; 粘蛋白类; 鼻粘膜; 呼吸道感染;

机译：Mucins;Nasal Mucosa;Respiratory Tract Infections;Interleukin-1;Muc5AC protein;粘蛋白类;鼻粘膜;呼吸道感染;

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1. Distribution of respiratory mucin proteins in human nasal mucosa. [J] . Groneberg DA, Peiser C, Dinh QT, The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. . 2003,第3期

机译：呼吸黏蛋白蛋白在人鼻黏膜中的分布。
2. Increased nasal patency caused by smoking and contraction of isolated human nasal mucosa. [J] . Maeda Y, Okita W, Ichimura K Rhinology . 2004,第2期

机译：吸烟和孤立的人鼻粘膜收缩引起的鼻通畅性增加。
3. Adhesion of Pseudomonas aeruginosa to respiratory mucins and expression of mucin-binding proteins are increased by limiting iron during growth. [J] . A Scharfman, H Kroczynski, C Carnoy, Infection and immunity . 1996,第12期

机译：铜绿假单胞菌对呼吸粘蛋白的粘附和粘蛋白结合蛋白的表达通过在生长过程中限制铁来增加。
4. BRAIN INJURY SCREENING DIAGNOSTICS FOR EMERGENCY MEDICINE: QUANTITATION OF CEREBROSPINAL FLUID SPECIFIC PROTEINS IN HUMAN NASAL DISCHARGE [C] . Akwasi A. Apori, Amy E. Herr International Conference on Miniaturized Systems for Chemistry and Life Sciences . 2011

机译：脑损伤筛查急诊药物诊断：脑鼻涕脑鼻液特异性蛋白质的定量
5. Analysis of protein-protein and protein-RNA interactions by severe acute respiratory syndrome nonstructural proteins and human karyopherin alpha 2. [D] . Miknis, Zachary Jason. 2009

机译：严重急性呼吸系统综合症非结构蛋白与人类核蛋白α2的蛋白质-蛋白质和蛋白质-RNA相互作用分析。
6. A reappraisal of the ultrastructure of the human respiratory nasal mucosa. [O] . A Busuttil, I A More, D McSeveney 1977

机译：人类呼吸道鼻粘膜超微结构的重新评估。
7. Herpes simplex virus type 1 penetrates the basement membrane in human nasal respiratory mucosa. [O] . Sarah Glorieux, Claus Bachert, Herman W Favoreel, 2011

机译：1型单纯疱疹病毒穿透人鼻呼吸道粘膜中的基底膜。

Distribution of respiratory mucin proteins in human nasal mucosa.

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