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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Intracordal injection of autologous fat in patients with unilateral laryngeal nerve paralysis: long-term results from the patient's perspective.
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Intracordal injection of autologous fat in patients with unilateral laryngeal nerve paralysis: long-term results from the patient's perspective.

机译：颈内动脉单侧喉神经麻痹患者的自体脂肪经皮内注射：从患者的角度来看是长期的结果。

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OBJECTIVE: Based on 80 patients with a previously nonsurgically treated unilateral laryngeal nerve paralysis (ULNP) and according to the patient's self-assessment, the authors document the long-term results achieved with the intracordal injection of autologous fat. STUDY DESIGN: Retrospective series, inception cohort. METHODS: Kaplan-Meier actuarial life table method and univariate analysis. RESULTS: None of the 80 patients died in the immediate postoperative period. Morbidity included hematoma at the donor site (in three patients), development of an intracordal cyst at the injection site (in three patients), fat extrusion at the injection site (in one patient), and temporary tracheotomy (in one patient). The initial and ultimate overall success rates were 96.2% and 77.2%, respectively. In univariate analysis, none of the variables under analysis (gender, age, associated neurological lesions, associated pneumonectomy, associated neoplasia, cause of the ULNP, side of the ULNP, nerve involved, delay between the onset of the ULNP and the intracordal injection, severity of the symptoms, mode of harvesting the autologous fat, and surgeon who performed the injection) was statistically related to the ultimate outcome after the intracordal injection of autologous fat. Among the group of 45 patients in whom the intracordal injection was initially considered to be successful with no further recovery of motion of the true vocal cord and a minimum survival of 12 months, the ultimate overall success rate was 62.2%, and the 3-month, 6-month, and 12-month Kaplan-Meier actuarial estimates for success were 91.1%, 72.8%, and 63.1%, respectively. CONCLUSIONS: In the present study, data confirm that the intracordal injection of autologous fat is a useful and safe procedure in patients with ULNP. However, the impossibility of exactly predicting the amount of resorption of the injected fat and the lack of predictability of the duration of the results, together with the good and stable results achieved at the authors' department with the medialization thyroplasty led the authors to reduce its current use.
机译：目的：基于80例先前未经手术治疗的单侧喉神经麻痹（ULNP）的患者，并根据患者的自我评估，作者记录了通过鞘内注射自体脂肪获得的长期结果。研究设计：回顾性系列研究，始创队列。方法：Kaplan-Meier精算寿命表法和单变量分析。结果：80例患者均没有在术后即刻死亡。发病率包括供体部位的血肿（三名患者），注射部位的结节内囊肿（三名患者），注射部位的脂肪挤出（一名患者）和临时气管切开术（一名患者）。最初和最终的总体成功率分别为96.2％和77.2％。在单变量分析中，未分析任何变量（性别，年龄，相关的神经系统病变，相关的肺切除术，相关的瘤形成，ULNP的病因，ULNP的一侧，所累及的神经，ULNP发作与皮质内注射之间的延迟，病情严重程度，自体脂肪的采集方式以及进行注射的外科医生）与经皮内注射自体脂肪后的最终结局在统计学上相关。在最初被认为是成功进行了鞘内注射且没有真正声带运动的进一步恢复且最低生存期为12个月的45例患者中，最终总体成功率为62.2％，而3个月Kaplan-Meier的6个月和12个月精算成功率分别为91.1％，72.8％和63.1％。结论：在本研究中，数据证实了鞘内注射自体脂肪对于ULNP患者是一种有用且安全的方法。但是，由于无法准确预测注射脂肪的吸收量，并且缺乏对结果持续时间的可预测性，加上作者在中位甲状腺成形术中取得的良好和稳定的结果，导致作者减少了其剂量。当前使用。

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