...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Adenoid cystic carcinoma of the sinonasal tract: treatment results.
【24h】

Adenoid cystic carcinoma of the sinonasal tract: treatment results.

机译：鼻窦腺样囊性癌：治疗结果。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: Malignancies arising from the sinonasal tract, which includes the nose, paranasal sinuses, and nasopharynx, are uncommon. Although adenoid cystic carcinoma (ACC) is the second most common cancer occurring in the sinonasal tract, only few studies have been reported. This retrospective review was performed to identify the clinical features and treatment outcomes of sinonasal ACC. METHODS: Thirty-five patients diagnosed and treated for ACC of the sinonasal tract were included in this study. Medical records, radiographs, and pathologic slides were retrospectively reviewed. RESULTS: In two thirds of the patients, the maxillary sinus was the site of origin and cribriform was the most common histologic subtype (61%). Seventy-one percent of the patients had advanced disease (T3, T4) at the time of diagnosis. Five-year overall survival rate was 86% and treatment failure occurred in 18 patients (51%). Five-year local recurrence rate and distant metastasis rate were 30% and 25%, respectively. Adjunctive radiotherapy appeared to reduce local recurrence. Presence of distant metastasis correlated with decreased 5-year survival (P = .001). Five-year survival rate after development of distant metastasis or local recurrence were 17% and 58%, respectively. CONCLUSIONS: Based on our findings, we suggest that sinonasal ACC be treated by a combined modality of radical surgery followed by postoperative radiation. The prognosis of sinonasal ACC seems to be determined by the presence of distant metastasis.
机译：目的：由鼻，鼻，鼻旁窦和鼻咽引起的鼻窦恶性肿瘤并不常见。尽管腺样囊性癌（ACC）是鼻窦道中第二大最常见的癌症，但仅报道了很少的研究。进行此回顾性研究以鉴定鼻窦ACC的临床特征和治疗结果。方法：本研究纳入了35例经鼻窦ACC诊断和治疗的患者。回顾性地回顾了病历，射线照相和病理切片。结果：三分之二的患者中，上颌窦是起源部位，筛状是最常见的组织学亚型（61％）。诊断时有71％的患者患有晚期疾病（T3，T4）。五年总生存率为86％，治疗失败的患者为18例（51％）。五年局部复发率和远处转移率分别为30％和25％。辅助放疗似乎减少了局部复发。远处转移的存在与5年生存率降低相关（P = .001）。远处转移或局部复发发生后的五年生存率分别为17％和58％。结论：根据我们的发现，我们建议鼻腔ACC可采用根治性手术联合术后放疗的联合方式进行治疗。鼻窦ACC的预后似乎取决于远处转移的存在。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号