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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Persistent allergic rhinitis has a moderate impact on the sense of smell, depending on both nasal congestion and inflammation.
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Persistent allergic rhinitis has a moderate impact on the sense of smell, depending on both nasal congestion and inflammation.

机译：持久性变应性鼻炎对嗅觉的影响中等，这取决于鼻塞和炎症。

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OBJECTIVES/HYPOTHESIS: A degree of smell disturbance has been found in seasonal and perennial allergic rhinitis, but alterations in olfaction in patients with persistent allergic rhinitis (PER) have not yet been evaluated. The aims of the study were to evaluate the impact of PER on the sense of smell, and to characterize this impact based on self-reported hyposmia (SRH) and PER severity. STUDY DESIGN/METHODS: A prospective controlled study was performed on 49 consecutive patients with PER. PER patients were subclassified depending on severity and the presence of SRH. Olfactory function was evaluated by the Barcelona Smell Test-24 (BAST-24) olfactometry for smell detection, identification, and forced choice for first and fifth cranial nerve (CN) dependent odors in comparison to a group of 60 healthy volunteers. In patients with SRH, obstruction was evaluated by peak nasal inspiratory flow (PNIF) and acoustic rhinometry; and nasal inflammation was evaluated by nasal nitric oxide (nNO). RESULTS: Most patients with PER (67%) presented SRH. Moderate/severe PER (84.8%) predominated among patients with SRH, while mild PER (75%) predominated among patients without SRH. Smell detection, identification, and forced choice tests were significantly worse in PER patients (P < .05) than in healthy controls for the odors related to the first and fifth CN. Among subgroups, patients with moderate/severe PER and/or with SRH presented a significant reduction in smell detection (P < .05) compared to healthy controls. Nasal NO correlated (R: 0.4; P < .05) with loss of smell. CONCLUSIONS: Patients with PER have a moderate loss of smell (BAST-24) with a higher impairment in those with self-reported hyposmia and moderate-to-severe PER. These results suggest that the sense of smell should be further investigated in all patients with allergic rhinitis, both in a clinical setting and in clinical trials.
机译：目的/假设：在季节性和常年性变应性鼻炎中已发现一定程度的气味紊乱，但尚未评估持续性变应性鼻炎（PER）患者嗅觉的改变。该研究的目的是评估PER对嗅觉的影响，并根据自我报告的低渗（SRH）和PER严重程度来表征这种影响。研究设计/方法：对49位连续的PER患者进行了一项前瞻性对照研究。根据严重程度和SRH的存在将PER患者分为亚类。与一组60名健康志愿者相比，通过Barcelona Smell Test-24（BAST-24）嗅觉测定法评估嗅觉功能，以检测，识别和强制选择第一和第五颅神经（CN）依赖的气味。在SRH患者中，通过峰值吸鼻血流量（PNIF）和声鼻法测定阻塞性;鼻腔一氧化氮（nNO）评估鼻腔炎症。结果：大多数PER患者（67％）出现SRH。在SRH患者中，中度/重度PER（84.8％）占优势，而在无SRH患者中轻度PER（75％）占优势。 PER患者的气味检测，鉴定和强制选择测试的不良表现（P <.05）比健康对照组的第一和第五CN相关气味明显差。在亚组中，与健康对照组相比，中度/重度PER和/或SRH的患者嗅觉检测显着降低（P <.05）。鼻NO与气味的丧失相关（R：0.4; P <.05）。结论：自我报告的低渗血症和中度至重度PER的患者，PER的患者具有中度嗅觉丧失（BAST-24），损伤程度更高。这些结果表明，在临床环境和临床试验中，所有过敏性鼻炎患者都应进一步研究嗅觉。

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