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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Predictors of olfactory dysfunction in patients with chronic rhinosinusitis.
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Predictors of olfactory dysfunction in patients with chronic rhinosinusitis.

机译：慢性鼻鼻窦炎患者嗅觉功能障碍的预测指标。

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OBJECTIVES: To measure the prevalence of and identify clinical characteristics associated with poor olfactory function in a large cohort of patients with chronic rhinosinusitis (CRS). STUDY DESIGN: Multi-institutional, cross sectional analysis. METHODS: An objective measure of olfactory dysfunction, the Smell Identification Test, demographic data, clinical factors, and comorbidity data were collected from a cohort of 367 patients who presented with CRS at three tertiary care centers. Data were analyzed using univariate and multivariate analyses. RESULTS: Sixty-four percent of men and women aged 18 to 64 had olfactory dysfunction whereas 95% of patients older than or equal to 65 years had olfactory dysfunction (P < .001); no significant difference was noted by gender. By multivariate logistic regression analysis, patients with nasal polyposis [Odds ratio (OR) 2.4, 95% confidence interval (CI) 1.3-4.2, P = .003] and patients older than or equal to 65 years (OR 10.0, 95% CI 2.3-43.7, P = .002) were at increased risk of hyposmia. Patients with nasal polyposis (OR 13.2, 95% CI 5.7-30.7, P < .001), asthma (OR 4.2, 95% CI 1.8-9.8, P = .001), older than or equal to 65 years (OR 15.6, 95% CI 2.3-104.9, P = .005), and smokers (OR 7.6, 95% CI 1.8-31.6, P = .005) were at increased risk of anosmia. CONCLUSIONS: Poor olfactory function is common in patients with CRS. Age, nasal polyposis, smoking, and asthma were significantly associated with olfactory dysfunction in patients with CRS. Neither prior endoscopic sinus surgery nor a history of allergic rhinitis was associated with olfactory dysfunction. Septal deviation and inferior turbinate hypertrophy were associated with normal olfactory function.
机译：目的：测量大量慢性鼻鼻窦炎（CRS）患者的嗅觉功能差的患病率，并确定其临床特征。研究设计：多机构的横截面分析。方法：客观测量嗅觉功能障碍，气味识别测试，人口统计学数据，临床因素和合并症数据来自三个三级护理中心的367名CRS患者。使用单变量和多变量分析来分析数据。结果：年龄在18至64岁之间的男性和女性中有64％患有嗅觉功能障碍，而年龄在等于或等于65岁的患者中有95％患有嗅觉功能障碍（P <.001）;性别没有显着差异。通过多因素logistic回归分析，鼻息肉病患者[几率（OR）2.4，95％置信区间（CI）1.3-4.2，P = .003]和年龄等于或大于65岁的患者（OR 10.0，95％CI 2.3-43.7，P = .002）患低钠血症的风险增加。鼻息肉病（OR 13.2，95％CI 5.7-30.7，P <.001），哮喘（OR 4.2，95％CI 1.8-9.8，P = .001），年龄大于或等于65岁（OR 15.6， 95％CI 2.3-104.9，P = .005）和吸烟者（OR 7.6，95％CI 1.8-31.6，P = .005）患失眠的风险增加。结论：CRS患者常见嗅觉功能差。 CRS患者的年龄，鼻息肉，吸烟和哮喘与嗅觉功能障碍显着相关。既往内窥镜鼻窦手术或过敏性鼻炎病史均与嗅觉功能障碍无关。鼻中隔偏曲和鼻甲肥大与嗅觉正常有关。

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