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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Comparison of extratemporal and intratemporal facial nerve injury models.
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Comparison of extratemporal and intratemporal facial nerve injury models.

机译：颞外和颞内面神经损伤模型的比较。

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OBJECTIVES/HYPOTHESIS: The purpose of this study was to compare functional recovery and motor nerve conduction following a distal extratemporal crush injury of the facial nerve to a more proximal intratemporal crush injury. STUDY DESIGN: Prospective, controlled animal study. METHODS: Adult male Sprague-Dawley rats were divided into four experimental groups: 1) extratemporal crush, 2) extratemporal sham-operated, 3) intratemporal crush, and 4) intratemporal sham-operated. Each group had an n of 4-9. The facial nerve was crushed near its exit from the stylomastoid foramen for extratemporal facial nerve injuries and within the facial canal in the temporal bone for intratemporal facial nerve injuries. Recovery times for the return of facial nerve functional parameters were compared between the two injury models. Motor nerve conduction studies were also done weekly to quantify the changes in peak amplitude and latency of evoked response. RESULTS: Rats receiving the extratemporal facial nerve injury recovered full facial function by approximately 2 weeks postoperative (wpo) and displayed normal peak amplitude and latency recordings by 4 wpo. In comparison, rats receiving the intratemporal facial nerve injury failed to reach complete functional recovery at the end of 8 wpo. Although latency of evoked response returned to normal by 2 weeks following the intratemporal injury, peak amplitude remained approximately 70% below normal at the end of 8 wpo. CONCLUSIONS: An intratemporal crush of the facial nerve leads to significantly delayed functional recovery and decreased motor nerve conduction as compared to an extratemporal crush, indicating that the location of injury strongly influences the recovery outcome.
机译：目的/假设：这项研究的目的是比较面部神经远端颞上压迫性损伤与颞侧近端压迫性损伤后的功能恢复和运动神经传导。研究设计：前瞻性对照动物研究。方法：将成年雄性Sprague-Dawley大鼠分为四个实验组：1）颞外压迫; 2）颞外假压; 3）颞内压迫; 4）颞内压。每组的n为4-9。面部神经在从吻合乳突孔的出口附近被压伤，以造成颞外面部神经损伤，在颞骨的面管内被压伤，造成颞内面部神经损伤。比较了两种损伤模型之间恢复面神经功能参数的恢复时间。每周还进行运动神经传导研究，以量化峰幅度和诱发反应潜伏期的变化。结果：大鼠颞部面神经损伤在术后约2周（wpo）时恢复了全部面部功能，并在4 wpo时显示出正常的峰值振幅和潜伏期记录。相比之下，在8 wpo结束时，遭受颞内面神经损伤的大鼠无法完全恢复功能。尽管颞部损伤后2周，诱发反应的潜伏期恢复正常，但在8 wpo结束时，峰值振幅仍比正常低约70％。结论：与颞外压迫相比，颞内压迫面神经会导致功能恢复显着延迟，运动神经传导减少，这表明损伤的位置会严重影响恢复结果。

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