...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Cardiology >Arterial age as a function of coronary artery calcium (from the Multi-Ethnic Study of Atherosclerosis (MESA)).
【24h】

Arterial age as a function of coronary artery calcium (from the Multi-Ethnic Study of Atherosclerosis (MESA)).

机译：动脉年龄与冠状动脉钙离子的关系（来自多民族动脉粥样硬化研究（MESA））。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

It has been proposed that coronary artery calcium (CAC) can be used to estimate arterial age in adults. Supporting this concept is that chronologic age, as used in cardiovascular risk assessment, is a surrogate for atherosclerotic burden. This measure can provide patients with a more understandable version of their CAC scores (e.g., "You are 55 years old, but your arteries are more consistent with an arterial age of 65 years"). The aim of this study was to describe a method of calculating arterial age by equating estimated coronary heart disease (CHD) risk for observed age and CAC. Arterial age is then the risk equivalent of CAC. Data from the Multi-Ethnic Study of Atherosclerosis (MESA), a cohort study of 6,814 participants free of clinical cardiovascular disease and followed for an average of 4 years, were used. Estimated arterial age was obtained as a simple linear function of log-transformed CAC. In a model for incident CHD risk controlling for age and arterial age, only arterial age was significant, indicating that observed age does not provide additional information after controlling for arterial age. Framingham risk calculated using this arterial age was more predictive of short-term incident coronary events than Framingham risk on the basis of observed age (area under the receiver-operating characteristic curve 0.75 for Framingham risk on the basis of observed age and 0.79 using arterial age, p = 0.006). In conclusion, arterial age provides a convenient transformation of CAC from Agatston units to a scale more easily appreciated by patients and treating physicians.
机译：已经提出，冠状动脉钙（CAC）可用于估计成人的动脉年龄。支持这一概念的是，心血管风险评估中使用的年代年龄是动脉粥样硬化负担的替代物。此度量可以为患者提供更易于理解的CAC分数版本（例如“您今年55岁，但您的动脉与65岁的动脉年龄更一致”）。这项研究的目的是描述一种计算动脉年龄的方法，方法是将估计的冠心病（CHD）风险与观察到的年龄和CAC等同起来。这样，动脉年龄就是CAC的风险当量。使用了多种族动脉粥样硬化研究（MESA）的数据，该队列研究对6,814名无临床心血管疾病的参与者进行了队列研究，平均随访了4年。通过对数转换的CAC的简单线性函数获得了估计的动脉年龄。在用于控制年龄和动脉年龄的事件性冠心病风险模型中，只有动脉年龄很重要，这表明在控制动脉年龄后观察到的年龄不能提供更多信息。根据观察到的年龄，使用该动脉年龄计算出的弗雷明汉风险比发生在弗拉明汉的风险更能预测短期突发性冠状动脉事件（根据观察者年龄，接受者操作特征曲线下的区域为0.75，根据观察到的年龄计算，弗雷明汉的风险为0.79;使用动脉年龄，则为0.79 ，p ＝ 0.006）。总之，动脉年龄可以方便地将CAC从Agatston单位转变为患者和治疗医师更容易理解的规模。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号