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首页> 外文期刊>The American Journal of Cardiology >Relation between individual plaque components and overall plaque burden in the prospective, multicenter virtual histology intravascular ultrasound registry.
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Relation between individual plaque components and overall plaque burden in the prospective, multicenter virtual histology intravascular ultrasound registry.

机译：在前瞻性，多中心虚拟组织学血管内超声检查中，单个斑块成分与总体斑块负担之间的关系。

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The impact of total plaque burden on absolute and relative amounts of each virtual histologic (VH) intravascular ultrasound (IVUS) plaque component has yet to be studied. We analyzed gray-scale and VH-IVUS findings in the first 990 patients enrolled in the 3,000+ patient global VH-IVUS registry. Whole pullback plaque burden and absolute and relative cross-sectional areas of fibrous tissue, fibrofatty plaque, dense calcium, and necrotic core were analyzed using a linear regression statistical model. Overall, absolute cross-sectional areas of each of the 4 plaque components correlated with total plaque cross-sectional area; however, the correlation between fibrous tissue and total plaque cross-sectional area was stronger than the correlation between fibrofatty plaque, dense calcium, or necrotic core and total plaque cross-sectional area. This was also true overall for each of the subgroups analyzed (gender, age, and presence/absence of acute coronary syndromes). Slope of the regression line relating each plaque component to overall plaque mass showed that 50% of the plaque cross-sectional area increase was because of fibrous tissue with a more gradual increase in fibrofatty plaque, dense calcium, and necrotic core. However, when comparing relative amounts of each plaque component with total plaque cross-sectional area, there was no significant relation between the increase in fibrous tissue, fibrofatty plaque, dense calcium, and necrotic core and the increase in total plaque cross-sectional area. In conclusion, only the absolute area of each plaque component correlated to overall plaque area, not the relative amount of each plaque; therefore, VH-IVUS plaque component increases must be analyzed by controlling for increases in plaque mass.
机译：总斑块负荷对每种虚拟组织学（VH）血管内超声（IVUS）斑块成分的绝对量和相对量的影响尚待研究。我们分析了3,000例患者以上全球VH-IVUS注册表中登记的前990名患者的灰度和VH-IVUS结果。使用线性回归统计模型分析了整个回拉斑块的负担以及纤维组织，纤维脂肪斑块，致密钙和坏死核的绝对和相对横截面积。总的来说，这4种噬菌斑成分中的每一个的绝对截面积与总菌斑截面积相关。然而，纤维组织与总斑块横截面面积之间的相关性强于纤维脂肪斑块，致密钙或坏死核心与总斑块横截面面积之间的相关性。对于所分析的每个亚组（性别，年龄和是否存在急性冠状动脉综合征），总体上也是如此。将每个噬斑成分与总噬斑质量相关联的回归线的斜率表明，噬斑横截面积增加的50％是由于纤维组织的纤维脂肪斑，致密钙和坏死核心的逐渐增加。但是，当将每个噬斑组分的相对量与总噬斑横截面面积进行比较时，纤维组织，纤维脂斑，致密钙和坏死核心的增加与总噬斑横截面积的增加之间没有显着关系。总之，只有每个噬菌斑成分的绝对面积与总噬菌斑面积相关，而不与每个噬菌斑的相对量相关;因此，必须通过控制斑块质量的增加来分析VH-IVUS斑块成分的增加。

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