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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Efficacy of leukotriene antagonists as concomitant therapy in allergic rhinitis.
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Efficacy of leukotriene antagonists as concomitant therapy in allergic rhinitis.

机译：白三烯拮抗剂在变应性鼻炎中作为伴随疗法的功效。

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OBJECTIVES/HYPOTHESIS: The symptoms of allergic rhinitis result from an immunoglobulin E-dependent mast cell activation cascade, marked by the release of inflammatory mediators, including histamine. Patients with perennial allergic rhinitis also have elevated levels of cysteinyl leukotrienes (CysLTs) in nasal lavage fluid. Histamine and CysLTs produce different responses in the pathogenesis of allergic rhinitis, and this study tested the hypothesis that the effects of combined antihistamine and leukotriene antagonist therapy would be more effective than antihistamine alone. STUDY DESIGN: Multicentered, prospective, randomized, placebo-controlled, parallel-group. METHODS: Three groups totaling 275 patients using: 1) fexofenadine alone, 2) fexofenadine with montelukast, or 3) fexofenadine with placebo, participated in a 21-day trial conducted during the spring pollen season. Objective analysis included pre- and poststudy physical examination findings and nasal resistance measurements. Subjective data gathered included a daily patient diary and pre- and poststudy patient satisfaction measurements. RESULTS: The group using both fexofenadine and montelukast showed significantly better control of nasal congestion both subjectively, using patient diary and visual analog scale evaluations, and objectively, using rhinomanometry and physical examination, compared to groups using antihistamine alone or with placebo. CONCLUSIONS: Our data provided both objective and subjective evidence that leukotriene receptor antagonist-antihistamine combination therapy is more effective than antihistamine alone in the control of allergic rhinitis symptoms.
机译：目的/假设：过敏性鼻炎的症状是由免疫球蛋白依赖的肥大细胞活化级联反应引起的，其特征在于炎症介质（包括组胺）的释放。患有常年性变应性鼻炎的患者鼻腔灌洗液中半胱氨酰白三烯（CysLTs）的水平也升高。组胺和CysLTs在变应性鼻炎的发病机理中产生不同的反应，这项研究验证了以下假设：抗组胺药和白三烯拮抗剂联合治疗比单独使用抗组胺药更有效。研究设计：多中心，前瞻性，随机，安慰剂对照，平行组。方法：三组共275名患者使用：1）单独的非索非那定，2）非索非那定联合孟鲁司特，或3）非索非那定联合安慰剂，参加了一个为期21天的春季花粉季节试验。客观分析包括研究前后的体格检查结果和鼻阻力测量。收集的主观数据包括每日患者日记以及研究前后的患者满意度测量。结果：与单独使用抗组胺药或安慰剂组相比，使用非索非那定和孟鲁司特的组在主观上，通过患者日记和视觉模拟量表评估，客观上，通过鼻压力测定法和体格检查，显示出对鼻塞的明显更好的控制。结论：我们的数据提供了客观和主观的证据，表明白三烯受体拮抗剂-抗组胺药联合治疗在控制变应性鼻炎症状方面比单独使用抗组胺药更有效。

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