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首页> 外文期刊>The American Journal of Cardiology >High-density lipoprotein cholesterol efflux, nitration of apolipoprotein A-I, and endothelial function in obese women
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High-density lipoprotein cholesterol efflux, nitration of apolipoprotein A-I, and endothelial function in obese women

机译：肥胖女性的高密度脂蛋白胆固醇外流，载脂蛋白A-I的硝化和内皮功能

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Subjects at risk of atherosclerosis might have dysfunctional high-density lipoprotein (HDL) despite normal cholesterol content in the plasma. We considered whether the efflux of excess cellular cholesterol to HDL from obese subjects is associated with impaired arterial endothelial function, a biomarker of cardiovascular risk. A total of 54 overweight (body mass index [BMI] 25 to 29.9 kg/m 2) or obese (BMI 30 kg/m 2) women, aged 46 ± 11 years, were enrolled in a worksite wellness program. The HDL cholesterol averaged 57 ± 17 mg/dl and was inversely associated with the BMI (r = -0.419, p = 0.002). Endothelial function was assessed using brachial artery flow-mediated dilation. Cholesterol efflux from 3H- cholesterollabeled baby hamster kidney cells transfected with the adenosine triphosphate-binding cassette transporter 1 showed 8.2% to 22.5% cholesterol efflux within 18 hours when incubated with 1% serum and was positively correlated with brachial artery flow-mediated dilation (p 0.05), especially in the 34 subjects with BMI 30 kg/m 2 (r = 0.482, p = 0.004). This relation was independent of age, HDL or low-density lipoprotein cholesterol concentrations in plasma, blood pressure, or insulin resistance on stepwise multiple regression analysis (β = 0.31, R 2 = 0.21, p = 0.007). Nitration of apolipoprotein A-I tyrosine residues (using sandwich enzyme-linked immunosorbent assay) was significantly greater in women with a BMI 30 kg/m 2 and the lowest cholesterol efflux than in women with a BMI of 25 to 29.9 kg/m 2 and the greatest cholesterol efflux (p = 0.01). In conclusion, we have shown that decreased cholesterol efflux by way of the adenosine triphosphate-binding cassette transporter 1 is associated with increased nitration of apolipoprotein A-I in HDL and is an independent predictor of impaired endothelial function in women with a BMI of 30 kg/m 2. This finding suggests that the functional measures of HDL might be better markers for cardiovascular risk than the HDL cholesterol levels in this population.
机译：尽管血浆中胆固醇含量正常，但有动脉粥样硬化风险的受试者可能具有功能异常的高密度脂蛋白（HDL）。我们考虑了肥胖受试者过量细胞胆固醇向HDL的流出是否与受损的动脉内皮功能有关，心血管功能是心血管疾病的生物标志物。总共54名超重（体重指数[BMI] 25至29.9 kg / m 2）或肥胖（BMI <30 kg / m 2）的女性年龄在46±11岁，参加了工作场所健康计划。 HDL胆固醇平均为57±17 mg / dl，与BMI呈负相关（r = -0.419，p = 0.002）。使用肱动脉血流介导的扩张来评估内皮功能。三磷酸腺苷结合盒转运蛋白1转染的3H-胆固醇标记的婴儿仓鼠肾细胞的胆固醇外流与1％血清孵育后18小时内显示8.2％至22.5％的胆固醇外流，并且与肱动脉血流介导的扩张呈正相关（p <0.05），尤其是BMI <30 kg / m 2的34位受试者（r = 0.482，p = 0.004）。在逐步多元回归分析中，这种关系与年龄，血浆中的HDL或血浆中的低密度脂蛋白胆固醇浓度，血压或胰岛素抵抗无关（β= 0.31，R 2 = 0.21，p = 0.007）。 BMI <30 kg / m 2且胆固醇外流最低的女性比BMI 25至29.9 kg / m 2的女性中载脂蛋白AI酪氨酸残基的硝化（使用三明治酶联免疫吸附测定）明显更高。最大胆固醇流出（p = 0.01）。总之，我们已经表明，通过三磷酸腺苷结合盒转运蛋白1降低胆固醇流出与HDL中载脂蛋白AI的硝化增加有关，并且是BMI <30 kg / m 2.这一发现表明，与该人群中的HDL胆固醇水平相比，HDL的功能性指标可能是心血管风险的更好标志。

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