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首页> 外文期刊>Biomechanics and modeling in mechanobiology >Mechanistic micro-structural theory of soft tissues growth and remodeling: tissues with unidirectional fibers
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Mechanistic micro-structural theory of soft tissues growth and remodeling: tissues with unidirectional fibers

机译：软组织生长和重塑的机械微观结构理论：单向纤维组织

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摘要

A new mechanistic theory was developed for soft tissues growth and remodeling (G&R). The theory considers tissues with unidirectional fibers. It is based on the loading-dependent local turnover events of each constituent and on the resulting evolution of the tissue micro-structure, the tissue dimensions and its mechanical properties. The theory incorporates the specific mechanical properties and turnover kinetics of each constituent, thereby establishing a general framework which can serve for future integration of additional mechanisms involved in G&R. The feasibility of the theory was examined by considering a specific realization of tissues with one fibrous constituent (collagen fibers), assuming a specific loading-dependent first-order fiber's turnover kinetics and the fiber's deposition characteristics. The tissue was subjected to a continuous constant rate growth. Model parameters were adopted from available data. The resulting predictions show qualitative agreement with a number of well-known features of tissues including the fibers' non-uniform recruitment density distribution, the associated tissue convex nonlinear stress-stretch relationship, and the development of tissue pre-stretch and pre-stress states. These results show that mechanistic micro-structural modeling of soft tissue G&R based on first principles can successfully capture the evolution of observed tissues' structure and size, and of their associated mechanical properties.
机译：为软组织的生长和重构（G＆R）开发了一种新的力学理论。该理论考虑具有单向纤维的组织。它基于每种成分的负荷相关的局部周转事件以及组织微观结构，组织尺寸及其机械性能的最终演变。该理论结合了每种成分的特定机械性能和翻转动力学，从而建立了一个通用框架，该框架可用于将来整合G＆R中涉及的其他机制。该理论的可行性通过考虑具有一种纤维成分（胶原纤维）的组织的特定实现进行了检验，并假设了特定的载荷依赖性一阶纤维的周转动力学和纤维的沉积特性。使组织连续恒定速率生长。从可用数据中采用模型参数。所得的预测表明与组织的许多众所周知的特征在质量上一致，包括纤维的不均匀募集密度分布，相关的组织凸非线性应力-拉伸关系以及组织预拉伸和预应力状态的发展。这些结果表明，基于第一原理的软组织G＆R的机械微观结构建模可以成功捕获观察到的组织的结构和大小及其相关机械性能的演变。

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