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首页> 外文期刊>The American Journal of Cardiology >Effect of carotid plaque screening using contrast-enhanced ultrasound on cardiovascular risk stratification
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Effect of carotid plaque screening using contrast-enhanced ultrasound on cardiovascular risk stratification

机译：对比增强超声检查颈动脉斑块对心血管风险分层的影响

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Cardiovascular risk stratification of asymptomatic patients is based on the assessment of risk factors. Noninvasive imaging of subclinical atherosclerosis may improve cardiovascular risk stratification, especially in patients with co-morbidities. The aim of this study was to investigate the effect of contrast-enhanced ultrasound (CEUS) of the carotid arteries on cardiovascular risk assessment. The study population consisted of 100 consecutive asymptomatic patients with ??1 clinical risk factor for atherosclerosis. Cardiovascular risk was estimated by calculating the Prospective Cardiovascular M??nster Heart Study (PROCAM) risk score. This score was divided into 3 subgroups: low (??5%), intermediate (6% to 19%), and high (??20%). Subclinical carotid atherosclerosis was assessed using standard ultrasound for intima-media thickness and plaque screening and CEUS for additional plaque screening. CEUS was performed using SonoVue contrast agent. Patients with subclinical atherosclerosis were considered to be at high cardiovascular risk. McNemar's test was used to compare PROCAM score to ultrasound findings. The mean PROCAM risk score was 9 ?? 10; the PROCAM risk score was low in 72 patients (72%), intermediate in 17 patients (17%), and high in 11 patients (11%). A total of 21 patients (21%) had abnormal carotid intima-media thickness, 77% had plaques on conventional carotid ultrasound, and 88% had plaques on standard carotid ultrasound combined with CEUS. Detection of atherosclerosis led to the reclassification of 79 patients (79%) to high cardiovascular risk (p <0.001). In conclusion, CEUS changes the risk category as estimated by a traditional risk stratification model in most asymptomatic patients. CEUS may thus be an additional method for cardiovascular risk prediction in patient groups with co-morbidities. ? 2013 Elsevier Inc. All rights reserved.
机译：无症状患者的心血管风险分层基于风险因素的评估。亚临床动脉粥样硬化的非侵入性成像可能会改善心血管疾病风险分层，尤其是在合并症患者中。这项研究的目的是调查颈动脉的超声造影（CEUS）对心血管风险评估的影响。研究人群包括100例连续无症状的患者，其临床危险因素为1。通过计算前瞻性心血管Msterster心脏研究（PROCAM）风险评分来评估心血管风险。该分数分为3个子组：低（？5％），中（6％至19％）和高（？20％）。使用标准超声评估亚临床颈动脉粥样硬化，以进行内膜中层厚度和斑块筛查，并使用CEUS进行其他斑块筛查。使用SonoVue造影剂进行CEUS。亚临床动脉粥样硬化患者被认为具有较高的心血管风险。 McNemar的测试用于比较PROCAM评分与超声检查结果。 PROCAM的平均风险评分为9 ?? 10; PROCAM风险评分在72例患者中（72％）低，在17例患者中（17％）为中级，在11例患者中（11％）高。共有21例患者（21％）颈动脉内中膜厚度异常，常规颈动脉超声斑块为77％，标准颈动脉超声联合CEUS斑块为88％。动脉粥样硬化的检测导致79例患者（79％）被重新分类为高心血管风险（p <0.001）。总之，CEUS改变了大多数无症状患者的传统危险分层模型所估计的危险类别。因此，CEUS可能是合并症患者组中心血管风险预测的另一种方法。 ？ 2013 Elsevier Inc.保留所有权利。

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