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首页> 外文期刊>The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition >Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial.
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Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial.

机译：以水或减肥饮料代替卡路里饮料以减轻成年人的体重：“每天选择健康选择意识”（CHOICE）随机临床试验的主要结果。

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BACKGROUND: Replacement of caloric beverages with noncaloric beverages may be a simple strategy for promoting modest weight reduction; however, the effectiveness of this strategy is not known. OBJECTIVE: We compared the replacement of caloric beverages with water or diet beverages (DBs) as a method of weight loss over 6 mo in adults and attention controls (ACs). DESIGN: Overweight and obese adults [n = 318; BMI (in kg/m(2)): 36.3 +/- 5.9; 84% female; age (mean +/- SD): 42 +/- 10.7 y; 54% black] substituted noncaloric beverages (water or DBs) for caloric beverages (>/=200 kcal/d) or made dietary changes of their choosing (AC) for 6 mo. RESULTS: In an intent-to-treat analysis, a significant reduction in weight and waist circumference and an improvement in systolic blood pressure were observed from 0 to 6 mo. Mean (+/-SEM) weight losses at 6 mo were -2.5 +/- 0.45% in the DB group, -2.03 +/- 0.40% in the Water group, and -1.76 +/- 0.35% in the AC group; there were no significant differences between groups. The chance of achieving a 5% weight loss at 6 mo was greater in the DB group than in the AC group (OR: 2.29; 95% CI: 1.05, 5.01; P = 0.04). A significant reduction in fasting glucose at 6 mo (P = 0.019) and improved hydration at 3 (P = 0.0017) and 6 (P = 0.049) mo was observed in the Water group relative to the AC group. In a combined analysis, participants assigned to beverage replacement were 2 times as likely to have achieved a 5% weight loss (OR: 2.07; 95% CI: 1.02, 4.22; P = 0.04) than were the AC participants. CONCLUSIONS: Replacement of caloric beverages with noncaloric beverages as a weight-loss strategy resulted in average weight losses of 2% to 2.5%. This strategy could have public health significance and is a simple, straightforward message. This trial was registered at clinicaltrials.gov as NCT01017783.
机译：背景：用无热量饮料代替无热量饮料可能是促进适度减轻体重的简单策略。但是，这种策略的有效性尚不清楚。目的：我们比较了以水或减肥饮料（DBs）代替卡路里饮料作为成年人和注意力控制（AC）体重减轻超过6个月的方法。设计：超重和肥胖的成年人[n = 318;体重指数（kg / m（2））：36.3 +/- 5.9; 84％女性;年龄（平均+/- SD）：42 +/- 10.7 y; 54％黑色]代替无热量饮料（水或DBs）代替高热量饮料（> / = 200 kcal / d），或在6个月内改变饮食选择（AC）。结果：在意向治疗分析中，从0到6 mo观察到体重和腰围明显减少，收缩压得到改善。 DB组在6 mo时的平均（+/- SEM）体重减轻为-2.5 +/- 0.45％，Water组为-2.03 +/- 0.40％，AC组为-1.76 +/- 0.35％;两组之间没有显着差异。 DB组在6 mo时实现5％体重减轻的机会大于AC组（OR：2.29; 95％CI：1.05，5.01; P = 0.04）。在水组中，相对于AC组，在6 mo（P = 0.019）时空腹血糖显着降低（P = 0.019），在3（P = 0.0017）和6（P = 0.049）mo时水合作用得到改善。在综合分析中，分配饮料替代品的参与者达到5％体重减轻的可能性（AC：2.07; 95％CI：1.02，4.22; P = 0.04）是AC参与者的2倍。结论：作为减肥策略，用非卡路里饮料代替卡路里饮料导致平均体重减轻2％至2.5％。该策略可能具有公共卫生意义，并且是一个简单，直接的信息。该试验已在Clinicaltrials.gov上注册为NCT01017783。

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