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首页> 外文期刊>The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition >Serum retinyl esters are not elevated in postmenopausal women with and without osteoporosis whose preformed vitamin A intakes are high.
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Serum retinyl esters are not elevated in postmenopausal women with and without osteoporosis whose preformed vitamin A intakes are high.

机译：在有和没有骨质疏松症且绝经后维生素A摄入量较高的绝经后妇女中，血清视黄醇酯含量没有升高。

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BACKGROUND: Recent observational studies suggest that preformed vitamin A (VA) intakes of 1500-2000 microg/d may increase the risk of osteoporosis and hip fracture. However, few studies have examined associations between biologic indicators of VA and osteoporosis. OBJECTIVE: This study characterized VA intake, serum VA, and bone turnover markers in postmenopausal women with and without osteoporosis. DESIGN: Bone density was measured by dual-energy X-ray absorptiometry. Subjects were separated into those with osteoporosis (n = 30) and those with normal bone density (n = 29). Women with osteopenia were excluded. Complete blood chemistries were obtained. Serum was analyzed for retinol, retinyl esters, and metabolites. Assays for 3 bone turnover markers were performed by using commercially available kits. Diet records were quantified. Logistic regression was used to test for an association between dietary and serum variables and osteoporosis. RESULTS: Dietary VA did not differ significantly between the groups but was nearly twice the Recommended Dietary Allowance in both groups. Body mass index (BMI) and serum triacylglycerols were significantly lower in the osteoporosis group. Retinyl esters were not elevated in either group, but a trend existed for the association of serum retinyl esters as a percentage of total VA with osteoporosis (P = 0.070) after adjustment for BMI and triacylglycerols in the statistical model. Milk, fruit, and vegetable intakes were below the current recommendations. CONCLUSIONS: Serum retinyl esters were not elevated in these postmenopausal women despite intakes of total VA that were nearly two-fold the Recommended Dietary Allowance. However, retinyl ester concentration (percentage of total VA) was marginally associated with osteoporosis and should be further investigated.
机译：背景：最近的观察研究表明，预先摄入的维生素A（VA）摄入量为1500-2000 microg / d可能会增加骨质疏松症和髋部骨折的风险。但是，很少有研究检查VA的生物学指标与骨质疏松症之间的关联。目的：本研究对患有和不患有骨质疏松症的绝经后妇女的VA摄入量，血清VA和骨转换指标进行了表征。设计：骨密度通过双能X射线吸收法测量。将受试者分为骨质疏松症（n = 30）和骨密度正常（n = 29）。患有骨质减少的女性被排除在外。获得了全血化学。分析血清中的视黄醇，视黄酯和代谢物。通过使用市售试剂盒进行3种骨转换标记的测定。饮食记录被量化。 Logistic回归用于检验饮食和血清变量与骨质疏松症之间的关联。结果：两组之间的膳食VA没有显着差异，但几乎是两组推荐膳食津贴的两倍。骨质疏松症组的体重指数（BMI）和血清三酰甘油含量显着降低。两组中的视黄酯均未升高，但在统计模型中调整了BMI和三酰甘油后，存在血清视黄酯占总VA百分比与骨质疏松的关联性趋势（P = 0.070）。牛奶，水果和蔬菜的摄入量低于目前的建议。结论：这些绝经后妇女的血清视黄醛酯水平并未升高，尽管其总VA摄入量约为推荐饮食标准的两倍。但是，视黄酯浓度（总VA的百分比）与骨质疏松症的关系很小，应进一步研究。

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