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首页> 外文期刊>The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition >Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants
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Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants

机译：高胆固醇血症参与者的降胆固醇食物与他汀类药物饮食组合的直接比较

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BACKGROUND: 3-Hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors reduce serum cholesterol and are increasingly advocated in primary prevention to achieve reductions in LDL cholesterol. Newer dietary approaches combining cholesterol-lowering foods may offer another option, but these approaches have not been compared directly with statins in the same persons. OBJECTIVE: The objective was to compare, in the same subjects, the cholesterol-lowering potential of a dietary portfolio with that of a statin. DESIGN: Thirty-four hyperlipidemic participants underwent all three 1-mo treatments in random order as outpatients: a very-low-saturated-fat diet (control diet), the same diet plus 20 mg lovastatin (statin diet), and a diet high in plant sterols (1.0 g/1000 kcal), soy-protein foods (including soy milks and soy burgers, 21.4 g/1000 kcal), almonds (14 g/1000 kcal), and viscous fibers from oats, barley, psyllium, and the vegetables okra and eggplant (10 g/1000 kcal) (portfolio diets). Fasting blood samples were obtained at 0, 2, and 4 wk. RESULTS: LDL-cholesterol concentrations decreased by 8.5+/-1.9%, 33.3+/-1.9%, and 29.6+/-1.3% after 4 wk of the control, statin, and portfolio diets, respectively. Although the absolute difference between the statin and the portfolio treatments was significant at 4 wk (P=0.013), 9 participants (26%) achieved their lowest LDL-cholesterol concentrations with the portfolio diet. Moreover, the statin (n=27) and the portfolio (n=24) diets did not differ significantly (P=0.288) in their ability to reduce LDL cholesterol below the 3.4-mmol/L primary prevention cutoff. CONCLUSIONS: Dietary combinations may not differ in potency from first-generation statins in achieving current lipid goals for primary prevention. They may, therefore, bridge the treatment gap between current therapeutic diets and newer statins.
机译：背景：3-羟基-3-甲基-戊二酰辅酶A（HMG-CoA）还原酶抑制剂可降低血清胆固醇，在一级预防中越来越多地提倡降低LDL胆固醇。结合降低胆固醇的食物的新型饮食方法可能提供了另一种选择，但这些方法尚未与同一人中的他汀类药物直接比较。目的：目的是在同一受试者中比较饮食组合和他汀类药物在降低胆固醇方面的潜力。设计：34名高脂血症参与者以门诊病人的随机顺序接受了全部三个1个月的治疗：超低脂饮食（对照饮食），相同饮食加上20毫克洛伐他汀（他汀类饮食）和高饮食植物固醇（1.0 g / 1000 kcal），大豆蛋白食品（包括豆浆和大豆汉堡21.4 g / 1000 kcal），杏仁（14 g / 1000 kcal）和燕麦，大麦，欧车前草和蔬菜秋葵和茄子（10克/ 1000大卡）（饮食组合）。在0、2和4周时获得空腹血液样品。结果：对照，他汀类和组合饮食4周后，LDL-胆固醇浓度分别降低了8.5 +/- 1.9％，33.3 +/- 1.9％和29.6 +/- 1.3％。尽管他汀类药物和组合治疗之间的绝对差异在4周时显着（P = 0.013），但有9名参与者（26％）在组合饮食中达到了最低的LDL-胆固醇浓度。此外，他汀类药物（n = 27）和有价证券（n = 24）饮食在将LDL胆固醇降低到3.4-mmol / L一级预防临界值以下的能力上没有显着差异（P = 0.288）。结论：在实现目前一级预防的脂质目标方面，饮食组合与第一代他汀类药物的功效可能没有差异。因此，它们可以弥合当前治疗性饮食与较新的他汀类药物之间的治疗差距。

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