• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American journal of drug and alcohol abuse >Characteristics of opioid-using pregnant women who accept or refuse participation in a clinical trial: Screening results from the MOTHER study
【24h】

Characteristics of opioid-using pregnant women who accept or refuse participation in a clinical trial: Screening results from the MOTHER study

机译：接受或拒绝参加临床试验的使用阿片类药物的孕妇的特征：MOTHER研究的筛查结果

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background:Although concerns arise about the generalizability of results from Randomized Controlled Trials (RCTs), few studies systematically examine this issue. Objectives: This study compared the characteristics of 427 opioid-using pregnant women who did (n = 208) and did not consent (n = 219) to enrollment in a multicenter clinical trial of agonist medications (i.e., the MOTHER study). Methods: Logistic regression models were used to compare consenters and non-consenters to examine the effect of screening variables on the likelihood of consenting. Results: Of nine characteristics examined, most differences did not reach statistical significance. Consenting participants were less likely than non-consenting women to be currently enrolled in a methadone maintenance program (74.5% vs. 84.5%, p = .01). Conclusion and Scientific Significance: These data show that the recruited sample of drug-dependent pregnantwomen enrolled in an intensiveRCTis representative of the larger population of treated opioid-dependent patients and supports the generalizability of randomized controlled trials in this population.
机译：背景：尽管人们对随机对照试验（RCT）的结果的可推广性表示担忧，但很少有研究系统地研究这个问题。目的：这项研究比较了427名使用阿片类药物的孕妇的特征（n = 208）和不同意（n = 219）参加了激动剂药物的多中心临床试验（即MOTHER研究）。方法：采用逻辑回归模型比较同意者和未同意者，以检验筛选变量对同意可能性的影响。结果：在检查的九个特征中，大多数差异未达到统计学显着性。同意参加者目前较未同意妇女参加美沙酮维持计划的可能性要低（74.5％比84.5％，p = 0.01）。结论和科学意义：这些数据表明，所招募的药物依赖性孕妇样本参加了代表大量阿片类药物依赖患者治疗的密集RCTis，并支持该人群中随机对照试验的普遍性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号