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首页> 外文期刊>The Philippine agriculturist >Leaf Extract from Cassia alata L. ('Akapulko') Induces Quinone Reductase and Competes for Estrogen Receptor Binding Indicating Cancer Chemopreventive Property
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Leaf Extract from Cassia alata L. ('Akapulko') Induces Quinone Reductase and Competes for Estrogen Receptor Binding Indicating Cancer Chemopreventive Property

机译：决明子的叶提取物（“ Akapulko”）诱导醌还原酶并与雌激素受体结合竞争，表明癌症的化学预防作用

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摘要

Hexane extract from the leaves of akapulko (Cassia alata L.) was tested for its Chemopreventive properties using the quinone reductase and the estrogen binding assays. The quinone reductase assay determines the ability of an extract to induce the production of quinone reductase, a Phase II enzyme that helps to inactivate carcinogenic compounds in vivo. The estrogen binding assay determines if a substance can compete with estrogen for binding with its target cells preventing its prolif-erative influence. This study demonstrated that a hexane fraction from C. alata L. leaf extract induced the activity of quinone reductase and was a competitor for estrogen receptor (ER) 13. In a related assay using Ishikawa endometrial cells, the estrogenic property ofthe extract was confirmed but like known phytoestrogens, the estrogenic activity is much weaker than that of estradiol. In an attempt to determine if the extract also has antioxidant properties like established phytoestrogens, the C. alata L. hexane fraction was also assayed for free radical scavenging activity. Results indicated that the extracts did not have free radical scavenging property.
机译：使用醌还原酶和雌激素结合试验测试了akapulko（Cassia alata L.）叶片中的己烷提取物的化学预防特性。醌还原酶测定法可确定提取物诱导醌还原酶（一种有助于在体内灭活致癌化合物的II期酶）产生的能力。雌激素结合测定法确定一种物质是否可以与雌激素竞争与其靶细胞的结合，从而阻止其增殖作用。这项研究表明，来自C. alata L.叶提取物的己烷馏分诱导了醌还原酶的活性，并且是雌激素受体（ER）13的竞争者。在使用石川子宫内膜细胞的相关测定中，证实了提取物的雌激素特性，像已知的植物雌激素一样，雌激素活性比雌二醇弱得多。为了确定提取物是否还具有确定的植物雌激素之类的抗氧化剂特性，还测定了C. alata L.己烷馏分的自由基清除活性。结果表明提取物不具有清除自由基的性质。

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