Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis

Korfei Martina; Skwarna Sylwia; Henneke Ingrid; MacKenzie BreAnne; Klymenko Oleksiy; Saito Shigeki; Ruppert Clemens; von der Beck Daniel; Mahavadi Poornima; Klepetko Walter; Bellusci Saverio; Crestani Bruno; Pullamsetti Soni Savai; Fink Ludger; Seeger Werner; Kraemer Oliver Holger; Guenther Andreas

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Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis

机译：散发性特发性肺纤维化中组蛋白脱乙酰基酶的异常表达和活性

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Background Activation and differentiation of fibroblasts into contractile protein-expressing myofibroblasts and their acquired apoptosis-resistant phenotype are critical factors towards the development of idiopathic pulmonary fibrosis (IPF), a fatal disease characterised by distorted pulmonary structure and excessive extracellular matrix (ECM) deposition. The molecular mechanisms underlying these processes in IPF remain incompletely understood. We investigated the possible implication of aberrant overexpression and activity of histone deacetylases (HDACs) in IPF.

机译：背景成纤维细胞的活化和分化为表达收缩蛋白的成纤维细胞及其获得的抗凋亡表型是发展为特发性肺纤维化（IPF）的关键因素，特发性肺纤维化是一种致命疾病，其特征是肺结构扭曲和细胞外基质（ECM）沉积过多。 IPF中这些过程的分子机制仍未完全了解。我们调查了IPF中异常过表达和组蛋白脱乙酰基酶（HDACs）活性的可能含义。

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《Thorax: The Journal of the British Thoracic Society》 |2015年第11期|共11页
作者
Korfei Martina; Skwarna Sylwia; Henneke Ingrid; MacKenzie BreAnne; Klymenko Oleksiy; Saito Shigeki; Ruppert Clemens; von der Beck Daniel; Mahavadi Poornima; Klepetko Walter; Bellusci Saverio; Crestani Bruno; Pullamsetti Soni Savai; Fink Ludger; Seeger Werner; Kraemer Oliver Holger; Guenther Andreas;
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正文语种 eng
中图分类呼吸系及胸部疾病;
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1. Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis [J] . Korfei Martina, Skwarna Sylwia, Henneke Ingrid, Thorax: The Journal of the British Thoracic Society . 2015,第11期

机译：散发性特发性肺纤维化中组蛋白脱乙酰基酶的异常表达和活性
2. Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo [J] . Ota Chiharu, Yamada Mitsuhiro, Fujino Naoya, Experimental Lung Research . 2015,第8期

机译：组蛋白脱乙酰基酶抑制剂可恢复肺泡上皮II型细胞中表面活性剂蛋白C的表达并减轻博来霉素诱导的体内肺纤维化
3. Effects of dynamic changes in histone acetylation and deacetylase activity on pulmonary fibrosis [J] . Mingwei Li, Yi Zheng, Huihui Yuan, International immunopharmacology . 2017,第期

机译：动态变化在组蛋白乙酰化和脱乙酰酶活性对肺纤维化的影响
4. Mga-Net: Multi-Scale Guided Attention Models for an Automated Diagnosis of Idiopathic Pulmonary Fibrosis (IPF) [C] . Wenxi Yu, Hua Zhou, Youngwon Choi, IEEE International Symposium on Biomedical Imaging . 2021

机译：MGA-NET：多尺度引导注意力模型，用于自动诊断特发性肺纤维化（IPF）
5. Cross-Talk Between Epigenetic Regulation And Mir-17~92 Cluster Expression In Idiopathic Pulmonary Fibrosis (IPF). [D] . Dakhlallah, Duaa Adel. 2011

机译：表观遗传调控与特发性肺纤维化（IPF）中Mir-17〜92簇表达之间的交叉讨论。
6. Pathologic Regulation of Collagen I by an Aberrant Protein Phosphatase 2A/Histone Deacetylase C4/MicroRNA-29 Signal Axis in Idiopathic Pulmonary Fibrosis Fibroblasts [O] . Wajahat Khalil, Hong Xia, Vidya Bodempudi, -1

机译：特发性肺纤维化成纤维细胞中异常蛋白磷酸酶2A /组蛋白去乙酰化酶C4 / MicroRNA-29信号轴对胶原蛋白I的病理调控
7. Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis [O] . Martina Korfei, Sylwia Skwarna, Ingrid Henneke, 2015

机译：散发性特发性肺纤维化中组蛋白脱乙酰酶的异常表达及活性

Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis

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