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首页> 外文期刊>Biological Psychology >Neural time course of threat-related attentional bias and interference in panic and obsessive-compulsive disorders
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Neural time course of threat-related attentional bias and interference in panic and obsessive-compulsive disorders

机译：恐慌和强迫症中与威胁相关的注意偏见和干扰的神经时程

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Attentional biases to threat are considered central to anxiety disorders, however physiological evidence of their nature and time course is lacking. Event-related potentials (ERPs) characterized sensory and cognitive changes while 20 outpatients with panic disorder (PD), 20 with obsessive-compulsive disorder (OCD), and 20 healthy controls (HCs) responded to the color (emotional Stroop task) or meaning of threatening and neutral stimuli. ERPs indicated larger P1 amplitude and longer N1 latency in OCD, and shorter P1 latency in PD, to threatening (versus neutral) stimuli, across instructions to attend to, or ignore, threat content. Emotional Stroop interference correlated with phobic anxiety and was significant in PD. Participants with emotional Stroop interference had augmented P1 and P3 amplitudes to threat (versus neutral) stimuli when color-naming. The results suggest early attentional biases to threat in both disorders, with disorder-specific characteristics. ERPs supported preferential early attentional capture and cognitive elaboration hypotheses of emotional Stroop interference.
机译：注意，对威胁的注意偏见被认为是焦虑症的关键，但是缺乏有关其性质和时程的生理证据。事件相关电位（ERP）表征了感觉和认知变化，而20名恐慌症（PD），20例强迫症（OCD）和20名健康对照（HCs）门诊患者对颜色（情绪性Stroop任务）或意义做出了反应威胁性和中性刺激。 ERPs指出，在涉及或忽略威胁内容的指令中，对威胁的威胁（相对于中性）刺激，OCD中的P1振幅较大，N1延迟较长，而PD中的P1延迟较短。情绪性Stroop干扰与恐惧症相关，在PD中很明显。在命名时，有情绪Stroop干扰的参与者增加了P1和P3幅度，以增强威胁（相对于中性）刺激。结果表明，这两种疾病都具有早期的注意偏见，具有疾病特有的特征。 ERP支持情绪Stroop干扰的优先早期注意捕获和认知加工假设。

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