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首页> 外文期刊>Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis >Expression of prothrombin fragment 1+2 in cancer tissue as an indicator of local activation of blood coagulation.
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Expression of prothrombin fragment 1+2 in cancer tissue as an indicator of local activation of blood coagulation.

机译：凝血酶原片段1 + 2在癌组织中的表达可作为凝血的局部活化指标。

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摘要

Immunohistochemistry was applied to AMeX-fixed tissue sections of 12 adenocarcinomas of the stomach (seven intestinal adenocarcinomas and five diffuse carcinomas), 12 adenocarcinomas of the pancreas (nine ductal adenocarcinomas and three signet ring carcinomas), and 12 squamous cell carcinomas of the larynx obtained at surgical resection to examine the possibility of extravascular activation of blood coagulation in cancer tissues by exploring the in loco patterns of distribution of fibrinogen, a final product of blood coagulation, fibrin, and a by-product of coagulation reactions (prothrombin fragment 1+2). Gastric, pancreatic, and laryngeal cancers exhibited fibrinogen antigen in abundance throughout the tumor stroma. Fibrin was detected along the edges of nests of carcinoma cells and at the host-tumor interface. Prothrombin fragment 1+2 was present in the blood vessels in areas of neoangiogenesis at the host-tumor interface (gastric and pancreatic cancer tissues) and on the tumor cell bodies (pancreatic and laryngeal cancer tissues). The presence of prothrombin fragment 1+2 in cancer tissues appears to be a good indicator of coagulation activation and thrombin generation at the tumor burden.
机译：免疫组织化学应用于AMeX固定的12个胃腺癌（七个肠腺癌和5个弥漫性癌），12个胰腺腺癌（9个导管腺癌和3个印戒环癌）以及12个喉鳞状细胞癌的组织切片。通过研究纤维蛋白原分布的局部模式，血液凝固的最终产物，纤维蛋白和凝血反应的副产物（凝血酶原片段1 + 2），在外科手术切除中检查癌症组织中血管外凝血激活的可能性）。胃癌，胰腺癌和喉癌在整个肿瘤基质中均表现出丰富的纤维蛋白原抗原。沿癌细胞巢边缘和宿主-肿瘤界面检测到纤维蛋白。凝血酶原片段1 + 2存在于宿主-肿瘤界面（胃和胰腺癌组织）和肿瘤细胞体（胰腺和喉癌组织）的新生血管生成区域的血管中。癌组织中凝血酶原片段1 + 2的存在似乎是在肿瘤负担下凝血激活和凝血酶生成的良好指标。

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