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首页> 外文期刊>Tierarztliche Praxis, Ausgabe K. Kleintiere >C-reactive protein (CRP) serum-concentration in dogs with impaired postoperative wound healing.
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C-reactive protein (CRP) serum-concentration in dogs with impaired postoperative wound healing.

机译：术后伤口愈合不良的狗中的C反应蛋白（CRP）血清浓度。

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摘要

Objective: The aim of this study is to evaluate the peri-operative course of the canine C-reactive protein (CRP) serum concentration in uncomplicated and complicated wound healing. Material and methods: Based on the postoperative course of wound healing, 99 dogs were assigned to the following groups: uncomplicated wound healing (control group, n=57), wound infection (n=11), wound dehiscence (n=5), seroma (n=6), haematoma (n=7), prolonged inflammatory condition (n=12), and other complications (n=1). Results: Patients with uncomplicated wound healing showed clinically a steady decrease of the initial local inflammatory reaction in the postoperative course. The CRP concentration was also characterized by an initial peak followed by a steady decline. Patients, whose wound healing was characterized by a prolonged or increasing inflammation, nearly always displayed unchanged high CRP concentrations or a second marked increase and higher CRP concentrations in comparison to the control group. This could be proved not only for patients with wound infection or wound dehiscence. Similar increases in the CRP concentration were found in patients without unambiguous signs of wound dehiscence or wound infection (prolonged inflammatory condition). In contrast to this, patients with seroma or haematoma showed neither a marked inflammatory reaction nor an increase of the CRP-concentration in the further postoperative course. Conclusion: Serial measurement of the CRP concentration is an objective parameter for the evaluation of wound healing. Clinical relevance: Unchanged high or again increasing CRP concentrations are under certain conditions, an indication for further diagnostic measurements and therapeutic consequences.
机译：目的：本研究的目的是评估犬C-反应蛋白（CRP）血清在非复杂和复杂伤口愈合中的围手术期过程。材料和方法：根据伤口愈合的过程，将99只狗分为以下几组：不复杂的伤口愈合（对照组，n = 57），伤口感染（n = 11），伤口裂开（n = 5），血清肿（n = 6），血肿（n = 7），炎症状态延长（n = 12）和其他并发症（n = 1）。结果：伤口愈合简单的患者在术后过程中临床上最初的局部炎症反应呈稳定下降趋势。 CRP浓度还具有一个初始峰值，然后逐渐下降的特征。与对照组相比，以伤口愈合时间长或炎症增加为特征的患者几乎总是显示出不变的高CRP浓度或第二次显着升高和更高的CRP浓度。不仅对于伤口感染或伤口裂开的患者，可以证明这一点。在没有明确的伤口开裂或伤口感染（长时间炎症状况）的患者中，CRP浓度也有类似的升高。与此相反，患有血清肿或血肿的患者在进一步的术后病程中既未显示出明显的炎症反应，也未显示CRP浓度增加。结论：CRP浓度的连续测量是评估伤口愈合的客观参数。临床相关性：在某些情况下，CRP浓度不变或不断升高，这指示进一步的诊断测量和治疗效果。

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