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Diagnostic tools for canine parvovirus infection

机译：犬细小病毒感染的诊断工具

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Canine parvovirus (CPV) infection is one of the most important and common infectious diseases in dogs, in particular affecting young puppies when maternal antibodies have waned and vaccine-induced antibodies have not yet developed. The mortality rate remains high. Therefore, a rapid and safe diagnostic tool is essential to diagnose the disease to 1) provide intensive care treatment and 2) to identify virus-shedding animals and thus prevent virus spread. Whilst the detection of antibodies against CPV is considered unsuitable to diagnose the disease, there are several different methods to directly detect complete virus, virus antigen or DNA. Additionally, to test in commercial laboratories, rapid in-house tests based on ELISA are available worldwide. The specificity of the ELISA rapid in-house tests is reported to be excellent. However, results on sensitivity vary and high numbers of false-negative results are commonly reported, which potentially leads to misdiagnosis. Polymerase chain reaction (PCR) is a very sensitive and specific diagnostic tool. It also provides the opportunity to differentiate vaccine strains from natural infection when sequencing is performed after PCR.
机译：犬细小病毒（CPV）感染是犬中最重要和最常见的传染病之一，尤其是当母体抗体减弱且尚未产生疫苗诱导的抗体时，幼犬就受到感染。死亡率仍然很高。因此，快速，安全的诊断工具对于诊断该疾病至关重要，以：1）提供重症监护治疗和2）识别出有病毒脱落的动物，从而防止病毒传播。尽管认为抗CPV抗体的检测不适合诊断该疾病，但是有几种不同的方法可以直接检测完整的病毒，病毒抗原或DNA。此外，要在商业实验室进行测试，全世界都可以使用基于ELISA的快速内部测试。据报道，ELISA快速内部测试的特异性非常出色。但是，灵敏度的结果各不相同，并且通常会报告大量的假阴性结果，这有可能导致误诊。聚合酶链反应（PCR）是一种非常灵敏且特异的诊断工具。在PCR之后进行测序时，它还提供了将疫苗株与自然感染区分开的机会。

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