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首页> 外文期刊>Toxicologic pathology >Proliferative and Nonproliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems
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Proliferative and Nonproliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems

机译：大鼠和小鼠中枢和周围神经系统的增殖性和非增殖性病变

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Harmonization of diagnostic nomenclature used in the pathology analysis of tissues from rodent toxicity studies will enhance the comparability and consistency of data sets from different laboratories worldwide. The INHAND Project (international i/ormonization of Nomenclature and .Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of four major societies of toxicologic pathology to develop a globally recognized nomenclature for proliferative and nonproliferative lesions in rodents. This article recommends standardized terms for classifying changes observed in tissues of the mouse and rat central (CNS) and peripheral (PNS) nervous systems. Sources of material include academic, government, and industrial histopathology databases from around the world. Covered lesions include frequent, spontaneous, and aging-related changes as well as principal toxicant-induced findings. Common artifacts that might be confused with genuine lesions are also illustrated. The neural nomenclature presented in this document is also available electronically on the Internet at the goRENI website (http://www.goreni.org/).
机译：啮齿类动物毒性研究对组织进行病理分析所用的诊断术语的统一将增强全球不同实验室数据集的可比性和一致性。 INHAND项目（大鼠和小鼠病变的国际命名和诊断标准）是毒理病理学四个主要学会共同发起的一项活动，目的是开发一种全球公认的啮齿动物增生性和非增生性病变术语。本文建议使用标准化术语对小鼠和大鼠中枢（CNS）和周围（PNS）神经系统的组织中观察到的变化进行分类。资料来源包括来自世界各地的学术，政府和工业组织病理学数据库。涵盖的病变包括频繁，自发和与衰老相关的变化，以及主要的毒物诱导的发现。还说明了可能与真正的病变相混淆的常见伪影。本文档中介绍的神经命名法也可以在互联网上的goRENI网站（http://www.goreni.org/）上以电子方式获得。

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