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首页> 外文期刊>Thermochimica Acta: An International Journal Concerned with the Broader Aspects of Thermochemistry and Its Applications to Chemical Problems >Studies of cimetidine pre-formulated and tablets for TG and DSC coupled to the photovisual system
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Studies of cimetidine pre-formulated and tablets for TG and DSC coupled to the photovisual system

机译：西咪替丁预先配制的片剂和片剂的TG和DSC与光视觉系统的结合研究

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摘要

This work studied the compatibility pre-formulated drug-excipient mixtures and tablets of cimetidine by TG and DSC coupled to a photovisualization system. The excipients PVPK30, explocel, microcel MC101, aerosil, and magnesium stearate were studied. Curves for the phase transitions of pre-formulated, microcel- and explocel-cimetidine were obtained. The results showed that the excipients, microcel and explocel, did not produce changes in the thermal behavior of cimetidine. This fact was confirmed by the DSC coupled photovisualization system. The rate constants for the thermal decomposition reaction were determined by an isothermal thermogravimetric (TG) method using the classical Arrhenius equations. The results showed that cimetidine tablets presented a stability higher than the cimetidine-excipient mixtures. (C) 2002 Elsevier Science B.V. All rights reserved. [References: 9]
机译：这项工作研究了配伍的西咪替丁的相容性预配制的药物-赋形剂混合物和片剂，通过TG和DSC与光可视化系统耦合。研究了赋形剂PVPK30，explocel，microcel MC101，aerosil和硬脂酸镁。获得了预先配制的微孔西米替丁和微孔西咪替丁的相变曲线。结果表明，辅料microcel和explocel不会改变西咪替丁的热行为。 DSC耦合的光学可视化系统已证实了这一事实。使用经典的Arrhenius方程通过等温热重（TG）方法确定热分解反应的速率常数。结果表明，西咪替丁片剂的稳定性高于西咪替丁-赋形剂混合物。 （C）2002 Elsevier Science B.V.保留所有权利。 [参考：9]

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