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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Characterization of Neisseria meningitidis isolates from Egypt using multilocus sequence typing
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Characterization of Neisseria meningitidis isolates from Egypt using multilocus sequence typing

机译：使用多基因座序列分型法鉴定埃及脑膜炎奈瑟氏菌分离株

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摘要

To characterize . Neisseria meningitidis isolates collected from cerebrospinal fluid of meningitis cases in Egypt (1998-2003) as part of surveillance studies, 67 isolates were serogrouped, tested for antibiotic sensitivity and analyzed using multilocus sequence typing (MLST).Results show that isolates expressing serogroup B (50.7%) and serogroup A (34.3%) antigens were predominant in Egypt during the surveillance period, possibly due to suppression of other serogroups by meningococcal vaccines in current use. Intermediate resistance to penicillin was observed in 71% of the isolates, suggesting a need for physicians to shift to third-generation cephalosporins during the empirical treatment of infection. Recurrent lineages of . N. meningitidis in Egypt appear to originate from Europe and other Middle Eastern countries. Of 19 sequence types detected, five were unique to Africa and 10 were not observed previously in the MLST database. The information obtained illustrates the changing dynamics of meningitis after vaccine introduction in Egypt.
机译：刻画。埃及（1998-2003）从脑膜炎病例脑脊液中收集的脑膜炎奈瑟氏菌分离株作为监测研究的一部分，对67株分离株进行了血清分组，测试了抗生素敏感性，并使用多位点序列分型（MLST）分析。在监测期间，埃及占50.7％）和A血清群（34.3％）抗原，主要是由于目前使用的脑膜炎球菌疫苗抑制了其他血清群。在71％的分离物中观察到了对青霉素的中等耐药性，这表明在经验性感染治疗过程中，医生需要转向第三代头孢菌素。复发的血统。埃及的脑膜炎奈瑟氏菌似乎起源于欧洲和其他中东国家。在检测到的19种序列类型中，有5种是非洲特有的，而以前在MLST数据库中没有观察到10种。获得的信息说明了在埃及引入疫苗后脑膜炎的变化动态。

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