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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Epidemiological and clinical features of cutaneous leishmaniases in Jenin District, Palestine, including characterisation of the causative agents in clinical samples
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Epidemiological and clinical features of cutaneous leishmaniases in Jenin District, Palestine, including characterisation of the causative agents in clinical samples

机译：巴勒斯坦杰宁区皮肤利什曼病的流行病学和临床特征，包括临床样本中致病菌的特征

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During 2002-2009, 466 cases of cutaneous leishmaniasis (CL) were reported from Jenin District, Palestine, affecting both genders. The average annual incidence was 23 cases per 100. 000 inhabitants, increasing with age in children. Most cases presented a single lesion, generally on the face. Diagnosis and species identification was done by applying internal transcribed spacer 1 (ITS1) RFLP analysis to 47 isolates, of which 44 (93.6%) were . Leishmania tropica and 3 (6.4%) were . L. major. RFLP analysis was also performed on 256 skin tissue scrapings spotted onto filter papers, showing that 138 (53.9%) were positive, of which 50.7% were infected with . L. tropica, 17.4% with . L. major and 2.9% with . L. donovani s.l., and 29.0% could not be identified. This is the first report from Palestine on human CL caused by . L. infantum. Nine of the strains of . L. tropica were subjected to multilocus enzyme electrophoresis, six of which belonged to the zymodeme MON-137 and three to a new zymodeme (MON-307). This separation was corroborated by excreted factor serotyping. This observation modifies the classical epidemiological view of CL in Palestine. Jenin District is an active focus of CL caused by . L. tropica, where . Phlebotomus sergenti, the putative vector, is abundant. These data suggest that CL is a zoonotic infection, but an animal reservoir has not been found.
机译：在2002年至2009年期间，巴勒斯坦杰宁区报告了466例皮肤利什曼病（CL）病例，这两种性别均受影响。年平均发病率为每100. 000居民23例，随着儿童年龄的增长而增加。大多数病例通常在脸上呈现单个病变。通过对47个分离株应用内部转录间隔区1（ITS1）RFLP分析来进行诊断和物种鉴定，其中44个（93.6％）是分离株。热带利什曼原虫和3（6.4％）为。 L.少校。还对点样在滤纸上的256个皮肤组织碎片进行了RFLP分析，显示138个（53.9％）为阳性，其中50.7％被感染。 L. tropica，占17.4％。 L. major和2.9％。不能鉴定出L. donovani s.l.和29.0％。这是巴勒斯坦关于由巴勒斯坦引起的人类CL的第一份报告。婴儿乳杆菌。九种沙门氏菌。对热带假丝酵母进行多位酶电泳，其中六个属于zymodeme MON-137，三个属于新的zymodeme（MON-307）。排泄因子血清分型证实了这种分离。这种观察改变了巴勒斯坦CL的经典流行病学观点。杰宁区是导致CL的积极焦点。 L. tropica，其中。假定的媒介香根草（Phlebotomus sergenti）丰富。这些数据表明CL是一种人畜共患感染，但尚未发现动物水库。

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