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首页> 外文期刊>Translational research: the journal of laboratory and clinical medicine >Evaluation of intraoperative fluorescence imaging-guided surgery in cancer-bearing dogs: a prospective proof-of-concept phase II study in 9 cases
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Evaluation of intraoperative fluorescence imaging-guided surgery in cancer-bearing dogs: a prospective proof-of-concept phase II study in 9 cases

机译：评估术中荧光成像引导的手术对癌症犬的影响：9例II期概念性前瞻性研究

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The objective was to prospectively evaluate the application of intraoperative fluorescence imaging (IOFI) in the surgical excision of malignant masses in dogs, using a novel lipid nanoparticle contrast agent. Dogs presenting with spontaneous soft-tissue sarcoma or subcutaneous tumors were prospectively enrolled. Clinical staging and whole-body computed tomography (CT) were performed. All the dogs received an intravenous injection of dye-loaded lipid nanoparticles, LipImage 815. Wide or radical resection was realized after CT examination. Real-time IOFI was performed before skin incision and after tumor excision. In cases of radical resection, the lymph nodes (LNs) were imaged. The margin/healthy tissues fluorescence ratio or LN/healthy tissues fluorescence ratio was measured and compared with the histologic margins or LN status. Nine dogs were included. Limb amputation was performed in 3 dogs, and wide resection in 6. No adverse effect was noted. Fluorescence was observed in all 9 of the tumors. The margins were clean in 5 of 6 dogs after wide surgical resection, and the margin/healthy tissues fluorescence ratio was close to 1.0 in all these dogs. Infiltrated margins were observed in 1 case, with a margin/healthy tissues fluorescence ratio of 3.2. Metastasis was confirmed in 2 of 3 LNs, associated with LN/healthy tissues fluorescence ratios of 2.1 and 4.2, whereas nonmetastatic LN was associated with a ratio of 1.0. LipImage 815 used as a contrast agent during IOFI seemed to allow for good discrimination between tumoral and healthy tissues. Future studies are scheduled to evaluate the sensitivity and specificity of IOFI using LipImage 815 as a tracer.
机译：目的是前瞻性地评估术中荧光成像（IOFI）在使用新型脂质纳米粒子造影剂对犬恶性肿块进行手术切除中的应用。前瞻性招募有自发性软组织肉瘤或皮下肿瘤的狗。进行临床分期和全身计算机断层扫描（CT）。所有的狗都接受了静脉注射染料负载的脂质纳米颗粒LipImage815。CT检查后实现了广泛或根治性切除。在皮肤切口之前和肿瘤切除之后进行实时IOFI。如果进行根治性切除，则对淋巴结（LNs）进行成像。测量边缘/健康组织荧光比或LN /健康组织荧光比，并将其与组织学边缘或LN状态进行比较。包括九只狗。肢体截肢3只，大范围切除6只。未观察到不良反应。在所有9种肿瘤中均观察到荧光。广泛的外科手术切除后，6只狗中有5只的边缘是干净的，所有这些狗的边缘/健康组织荧光比都接近1.0。 1例观察到浸润的边缘，边缘/健康组织的荧光比为3.2。在3个LN中确认有2个转移，与LN /健康组织的荧光比为2.1和4.2相关，而非转移性LN与1.0个比相关。在IOFI期间用作造影剂的LipImage 815似乎可以很好地区分肿瘤组织和健康组织。使用LipImage 815作为示踪剂，计划进行进一步的研究以评估IOFI的敏感性和特异性。

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