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首页> 外文期刊>Transfusion science >Comparison of platelet immunity in patients with SLE and with ITP.
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Comparison of platelet immunity in patients with SLE and with ITP.

机译：SLE和ITP患者血小板免疫的比较。

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Idiopathic thrombocytopenic purpura (ITP) is characterized by the development of a specific anti-platelet autoantibody immune response mediating the development of thrombocytopenia. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of a wide variety of autoantibodies. In 15-20% of SLE cases, patients develop thrombocytopenia which appears to be autoimmune in nature (SLE-TP). To better understand the pathogenesis of the thrombocytopenia associated with SLE, we investigated the overlapping platelet and cellular immune features between SLE and ITP. Thirty-one patients with SLE, eight with SLE-TP, and 17 with ITP, were studied and compared to 60 healthy controls. We evaluated platelet-associated IgG, platelet microparticles, reticulated platelets, platelet HLA-DR expression, in vivo cytokine levels, lymphocyte proliferation, and the T lymphocyte anti-platelet immune response in these patients. Patients with SLE-TP and those with ITP had increased platelet-associated IgG, an increased percentage of platelet microparticles, a higher percentage of reticulated platelets and larger platelets, suggesting antibody-mediated platelet destruction and increased platelet production. More than 50% of patients with ITP had increased HLA-DR on their platelet surface whereas subjects with SLE-TP did not. Analysis of serum cytokines demonstrated increased levels of IL-10, IL-15 and TNF-alpha in patients with SLE, but in those with ITP, only increased levels of IL-15 were seen, no increases in any of these cytokines were observed in patients with in SLE-TP. The ability of lymphocytes to proliferate in response to phorbol myristate acetate (PMA) stimulation was increased in SLE-TP, but was normal in both SLE and ITP. Lymphocytes from subjects with ITP displayed an increased ability to proliferate on exposure to platelets, in contrast, those with SLE-TP did not. While the number of subjects evaluated with SLE-TP was small, these data reveal a number of differences in the immunopathogenesis between SLE-TP and ITP.
机译：特发性血小板减少性紫癜（ITP）的特征是介导血小板减少症的特异性抗血小板自身抗体免疫反应的发展。系统性红斑狼疮（SLE）是一种自身免疫性疾病，其特征是产生多种自身抗体。在15％至20％的SLE病例中，患者会出现血小板减少症，这似乎是自身免疫性疾病（SLE-TP）。为了更好地了解与SLE相关的血小板减少症的发病机理，我们研究了SLE和ITP之间重叠的血小板和细胞免疫特征。研究了SLE患者31例，SLE-TP患者8例，ITP患者17例，并与60例健康对照者进行了比较。我们评估了这些患者的血小板相关IgG，血小板微粒，网状血小板，血小板HLA-DR表达，体内细胞因子水平，淋巴细胞增殖和T淋巴细胞抗血小板免疫反应。 SLE-TP患者和ITP患者的血小板相关IgG含量增加，血小板微粒百分比增加，网状血小板百分比更高和血小板更大，表明抗体介导的血小板破坏和血小板生成增加。超过50％的ITP患者血小板表面HLA-DR升高，而SLE-TP患者则没有。血清细胞因子的分析表明，SLE患者中IL-10，IL-15和TNF-α的水平升高，但是在ITP患者中，仅观察到IL-15的水平升高，而在这些患者中未观察到任何这些细胞因子的升高。 SLE-TP患者。在SLE-TP中，响应佛波醇肉豆蔻酸酯乙酸盐（PMA）刺激，淋巴细胞的增殖能力增加，但在SLE和ITP中均正常。来自ITP受试者的淋巴细胞在暴露于血小板后显示出增加的增殖能力，相比之下，具有SLE-TP的受试者则没有。尽管使用SLE-TP评估的受试者人数很少，但这些数据表明SLE-TP和ITP之间的免疫发病机制存在许多差异。

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