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首页> 外文期刊>Trends in Plant Science >Proteins, chlorophylls and lipids: X-ray analysis of a three-way relationship
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Proteins, chlorophylls and lipids: X-ray analysis of a three-way relationship

机译:蛋白质,叶绿素和脂质:X射线分析三向关系

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Photosynthetic reaction centres and light harvesting complexes have been at the forefront of crystallographic studies of integral membrane proteins. In recent years, there have been spectacular advances in our understanding of the structure of (bacterio)chlorophyll-containing membrane proteins from oxygenic and anoxygenic phototrophs. In these complex structures, the protein scaffold encases different combinations of cofactors and interacts with several tightly bound lipid species that play a variety of hitherto unrecognized structural roles. Some of these lipids have relevance to the physiological function of the protein, whereas others are important for the formation of highly ordered crystals. The first site-directed mutagenesis studies of individual lipid binding sites have now underlined the importance of the lipid component for the structural stability of protein-cofactor-lipid complexes.
机译:光合反应中心和光收集复合体一直是整合膜蛋白晶体学研究的最前沿。近年来,在我们对含氧和无氧光养植物的含(细菌)叶绿素的膜蛋白结构的理解方面取得了惊人的进展。在这些复杂的结构中,蛋白质支架包裹着辅因子的不同组合,并与几个紧密结合的脂质种类相互作用,这些脂质种类起着迄今无法识别的各种结构作用。这些脂质中的一些与蛋白质的生理功能有关,而其他一些对于形成高度有序的晶体很重要。单个脂质结合位点的第一个定点诱变研究现在强调了脂质组分对于蛋白质-辅因子-脂质复合物的结构稳定性的重要性。

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