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Emerging roles for RNA polymerase II CTD in Arabidopsis

机译:RNA聚合酶II CTD在拟南芥中的新兴作用

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Post-translational modifications of the carboxy-terminal domain of the largest subunit of RNA polymerase II (RNAPII CTD) provide recognition marks to coordinate recruitment of numerous nuclear factors controlling transcription, cotranscriptional RNA processing, chromatin remodeling, and RNA export. Compared with the progress in yeast and mammals, deciphering the regulatory roles of position-specific combinatorial CTD modifications, the so-called CTD code, is still at an early stage in plants. In this review, we discuss some of the recent advances in understanding of the molecular mechanisms controlling the deposition and recognition of RNAPII CTD marks in plants during the transcriptional cycle and highlight some intriguing differences between regulatory components characterized in yeast, mammals, and plants.
机译:RNA聚合酶II(RNAPII CTD)最大亚基的羧基末端结构域的翻译后修饰提供了识别标记,可协调募集控制转录,共转录RNA加工,染色质重塑和RNA输出的众多核因子的募集。与酵母和哺乳动物的研究进展相比,在植物中,对位置特定的组合CTD修饰(即所谓的CTD代码)的调节作用的解读仍处于早期阶段。在这篇综述中,我们讨论了在转录周期中控制植物中RNAPII CTD标记的沉积和识别的分子机制的理解方面的一些最新进展,并重点介绍了以酵母,哺乳动物和植物为特征的调节成分之间的一些有趣差异。

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