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Viral polypeptide fragments that bind to the C-terminal domain (CTD) of cellular RNA polymerase II and uses thereof

机译：结合细胞RNA聚合酶II的C端结构域（CTD）的病毒多肽片段及其用途

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摘要

The present invention provides compounds in silico that reduce or block the binding of a viral RNA-dependent RNA polymerase from the Orthomyxoviridae or a variant thereof to its ligand (preferably cellular RNA polymerase II, more preferably CTD). The invention relates to a method of identifying, as well as a method of producing the identified compound. The invention also relates to compounds identifiable and / or manufacturable by said method. The invention also relates to an antibody against the binding site of an RNA-dependent RNA polymerase to its ligand (particularly cellular RNA polymerase II, in particular Pol II CTD), as well as a nucleic acid encoding the antibody and a vector comprising the nucleic acid. The present invention relates to a pharmaceutical composition that can be produced according to the method and / or comprises the compound, the antibody, the nucleic acid or the vector. The invention also relates to the use of the compound, the antibody, the nucleic acid, the vector or the medicament in the treatment, amelioration or prevention of a disease state caused by a viral infection by a virus of the Orthomyxoviridae family.

机译：本发明提供了计算机合成的化合物，其减少或阻断来自正粘病毒科或其变体的病毒RNA依赖性RNA聚合酶与其配体的结合（优选细胞RNA聚合酶II，更优选CTD）。本发明涉及一种鉴定方法以及生产所鉴定化合物的方法。本发明还涉及通过所述方法可鉴定和/或可制造的化合物。本发明还涉及针对RNA依赖性RNA聚合酶与其配体（特别是细胞RNA聚合酶II，特别是Pol II CTD）结合位点的抗体，以及编码该抗体的核酸和包含该核酸的载体酸。本发明涉及一种药物组合物，其可以根据该方法生产和/或包含化合物，抗体，核酸或载体。本发明还涉及化合物，抗体，核酸，载体或药物在治疗，改善或预防由正粘病毒科病毒感染病毒引起的疾病状态中的用途。

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公开/公告号JP2019528508A

专利类型
公开/公告日2019-10-10

原文格式PDF
申请/专利权人ヨーロピアンモレキュラーバイオロジーラボラトリー;
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申请/专利号JP20190500265
发明设计人スティーブン・キューザック;アレクサンダー・プルーク;マリア・ルカルスカ;
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申请日2017-07-07
分类号G16B15/30;C12N9/10;C12Q1/48;C07K16/40;C12N15/13;C12N15/63;C12N1/15;C12N1/19;C12N1/21;C12N5/10;A61P43;A61P31/14;A61K45;A61K48;A61K39/395;G01N33/50;G01N33/15;
国家 JP
入库时间 2022-08-21 12:22:11

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