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Trans-acting small interfering RNA4: key to nutraceutical synthesis in grape development?

机译:反式小干扰RNA4:葡萄发育中营养保健合成的关键?

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The facility and versatility of microRNAs (miRNAs) to evolve and change likely underlies how they have become dominant constituents of eukaryotic genomes. In this opinion article I propose that trans-acting small interfering RNA gene 4 (TAS4) evolution may be important for biosynthesis of polyphenolics, arbuscular symbiosis, and bacterial pathogen etiologies. Expression-based and phylogenetic evidence shows that TAS4 targets two novel grape (Vitis vinifera L.) MYB transcription factors (VvMYBA6, VvMYBA7) that spawn phased small interfering RNAs (siRNAs) which probably function in nutraceutical bioflavonoid biosynthesis and fruit development. Characterization of the molecular mechanisms of TAS4 control of plant development and integration into biotic and abiotic stress-and nutrient-signaling regulatory networks has applicability to molecular breeding and the development of strategies for engineering healthier foods.
机译:微小RNA(miRNA)进化和改变的便利性和多功能性可能是它们成为真核基因组主要成分的基础。在这篇意见书中,我提出反式小干扰RNA基因4(TAS4)的进化对于多酚类生物合成,丛枝共生和细菌病原体病因可能很重要。基于表达的系统发育证据表明,TAS4靶向两个新颖的葡萄(Vitis vinifera L.)MYB转录因子(VvMYBA6,VvMYBA7),这些转录因子产生了分阶段的小干扰RNA(siRNA),这些RNA可能在营养保健品类黄酮的生物合成和果实发育中起作用。 TAS4控制植物发育并整合到生物和非生物胁迫和营养素信号调节网络中的分子机制的表征可用于分子育种和工程化更健康食品的策略开发。

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