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首页> 外文期刊>Tumori. >Differential diagnosis of Krukenberg tumors using multivariate analysis.
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Differential diagnosis of Krukenberg tumors using multivariate analysis.

机译：使用多变量分析对克鲁肯伯格肿瘤进行鉴别诊断。

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AIMS AND BACKGROUND: Krukenberg tumors are ovarian metastases from a gastroenteric malignancy in 90% of cases. At present, diagnostic imaging techniques (US, CT, MRI) do not provide any reliable diagnostic criteria to differentiate these metastases from ovarian primaries. We tried to use multivariate analysis to distinguish malignant ovarian primaries from Krukenberg tumors based on their differential natural history. PATIENTS AND METHODS: We retrospectively compared the CT findings of Krukenberg tumors (47 patients, 79 masses, only from gastroenteric malignancy) with CT findings of primary epithelial ovarian cancers (46 patients, 67 masses). We compared the same independent variables in the two groups: age, morphology, margins, carcinomatosis, bilateral versus unilateral involvement, ascites, lymph node involvement, metastases on the basis of multivariate analysis. RESULTS: According to the best fitted model, clear-cut margins (OR: 3.75; 95% CI: 1.14-9.72) and the presence of carcinomatosis (OR: 4.21; 95% CI: 1.51-11.72) were the strongest predictors of a diagnosis of Krukenberg tumor. In contrast, the presence of ascites was more likely to be a protective factor (OR: 0.22; 95% CI: 0.08-0.62). CONCLUSIONS: We can try to make a differential diagnosis between a metastatic lesion from the gastroenteric tract and a primary adnexal lesion based on the multivariate statistical analysis of intraperitoneal spread of the different types of cancer rather than on morphologic findings at CT.
机译：目的和背景：克鲁肯伯格肿瘤是90％的胃肠道恶性肿瘤引起的卵巢转移。目前，诊断成像技术（US，CT，MRI）尚未提供任何可靠的诊断标准来区分这些转移灶与卵巢原发灶。我们试图使用多变量分析根据其不同的自然史将恶性卵巢原发与克鲁肯伯格肿瘤区分开。病人和方法：我们回顾性地比较了克鲁肯伯格肿瘤的CT表现（47例，占79例，仅来自消化道恶性肿瘤）与原发性上皮性卵巢癌的CT表现（46例，占67例）。我们在多变量分析的基础上比较了两组中相同的独立变量：年龄，形态，切缘，癌变，双侧或单侧受累，腹水，淋巴结受累，转移。结果：根据最佳拟合模型，明确的切缘（OR：3.75; 95％CI：1.14-9.72）和癌变的存在（OR：4.21; 95％CI：1.51-11.72）是最有力的预测指标。诊断克鲁肯伯格肿瘤。相反，腹水的存在更有可能是保护因素（OR：0.22; 95％CI：0.08-0.62）。结论：我们可以基于对不同类型癌症的腹膜内扩散的多变量统计分析，而不是根据CT的形态学发现，来鉴别胃肠道转移性病变和原发性附件病变。

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