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Clinical implication of CD166 expression in salivary gland tumor

机译：涎腺肿瘤中CD166表达的临床意义

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CD166 is a glycoprotein of immunoglobulin superfamily of adhesion molecules which is overexpressed in many tumors. However, no published literature was found concerning CD166 expression in salivary gland tumor. The purpose of this study was to examine the CD166 expression in the salivary gland tumor by an immunohistochemical approach, to examine the clinical implication of this marker in the prognosis and diagnosis of the salivary gland tumor. In this study, 45 samples of salivary tumors from Khalili Hospital archive including 15 cases of pleomorphic adenoma, 16 cases of mucoepidermoid carcinoma, 14 cases of adenoid cystic carcinoma, and 15 normal salivary glands were selected for immunohistochemistry (IHC) method staining for CD166. CD166 immunoreactivity inmalignant tumors (adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC)) (56.7 +/- 14.05) was significantly higher than that of pleomorphic adenoma (PA) (34.3 +/- 17.07) (P<0.000) and higher in the PA than normal salivary gland (13.2 +/- 12.1) (P=0.001). CD166 expression was significantly higher in the high-grade tumors (90.3 +/- 11.07) compared to low-grade (65.11 +/- 27.08) malignant tumors (P=0.002). CD166 expression showed a significant association with tumor size and the clinical stage (P<0.001). In conclusion, an overexpression of CD166 was detected in the benign and malignant salivary gland tumors and its expression in the malignant tumor was associated with the aggressive behavior and tumor progression. For this reason, CD166 may be one of the potential biomarkers for predicting tumor behavior in the prognosis of this disease.
机译：CD166是粘附分子的免疫球蛋白超家族的糖蛋白，在许多肿瘤中都过表达。然而，没有发现关于唾液腺肿瘤中CD166表达的公开文献。这项研究的目的是通过免疫组织化学方法检查唾液腺肿瘤中CD166的表达，并检查该标志物在唾液腺肿瘤的预后和诊断中的临床意义。在这项研究中，选择了哈利利医院档案馆的45例唾液肿瘤样本，包括15例多形腺瘤，16例粘液表皮样癌，14例腺样囊性癌和15例正常唾液腺进行CD166免疫组织化学（IHC）染色。 CD166免疫反应性恶性肿瘤（腺样囊性癌（ACC）和粘液表皮样癌（MEC））（56.7 +/- 14.05）显着高于多形性腺瘤（PA）（34.3 +/- 17.07）（P <0.000）和更高PA中的唾液腺比正常唾液腺（13.2 +/- 12.1）（P = 0.001）。与低度恶性肿瘤（65.11 +/- 27.08）相比，高度肿瘤（90.3 +/- 11.07）中的CD166表达明显更高（P = 0.002）。 CD166表达与肿瘤大小和临床分期有显着相关性（P <0.001）。总之，在良性和恶性唾液腺肿瘤中检测到CD166的过表达，其在恶性肿瘤中的表达与侵袭行为和肿瘤进展相关。因此，CD166可能是预测该疾病预后中肿瘤行为的潜在生物标志物之一。

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