Role of complementary proteins in autoimmunity: an old idea re-emerges with new twists.

McGuire KL; Holmes DS

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Role of complementary proteins in autoimmunity: an old idea re-emerges with new twists.

机译：互补蛋白在自身免疫中的作用：一个古老的想法以新的曲折重新出现。

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It has been suggested that complementary proteins are involved in autoimmunity through a network involving idiotype-anti-idiotype reactions termed 'autoantigen complementarity'. We propose that complementary proteins, which occur naturally or result from cellular dysfunction, might be more common than recognized currently. This implies that the role of complementary proteins in autoimmunity merits increasing investigation. The concept of complementary proteins is reviewed here and, also, new ideas are presented that underscore the role of open-reading frames in frame -1 of recognized genes in the production of complementary proteins (frame -1 is the reverse complement sequence of a gene that uses the antisense of the codons of frame +1). Furthermore, a novel role for palindromic sequences in autoimmunity and a new model explaining how abzymes and autoantigen complementarity might be related are proposed.

机译：已经提出，互补蛋白通过涉及称为“自身抗原互补性”的独特型-抗独特型反应的网络参与自身免疫。我们提出，天然存在的或由细胞功能障碍导致的互补蛋白可能比目前公认的更为普遍。这表明互补蛋白在自身免疫中的作用值得进一步研究。本文对互补蛋白的概念进行了综述，并提出了新的观点，这些思想强调了在已识别基因的第-1号框架中开放阅读框在互补蛋白生产中的作用（第-1号框架是基因的反向互补序列使用第+1帧密码子的反义）。此外，提出了回文序列在自身免疫中的新作用，并提出了一种新的模型，该模型解释了抗体酶和自身抗原互补性如何相关。

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《Trends in immunology》 |2005年第7期|共6页
作者
McGuire KL; Holmes DS;
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正文语种 eng
中图分类医学免疫学;
关键词
Autoimmunity; Proteins; 自身免疫; 蛋白质类;

机译：Autoimmunity;Proteins;自身免疫;蛋白质类;

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专利

1. Role of complementary proteins in autoimmunity: an old idea re-emerges with new twists. [J] . McGuire KL, Holmes DS Trends in immunology . 2005,第7期

机译：互补蛋白在自身免疫中的作用：一个古老的想法以新的曲折重新出现。
2. Increased nitration and carbonylation of proteins in MRL+/+ mice exposed to trichloroethene: potential role of protein oxidation in autoimmunity. [J] . Wang G, Wang J, Ma H Toxicology and Applied Pharmacology . 2009,第2期

机译：暴露于三氯乙烯的MRL + / +小鼠中蛋白质的硝化和羰基化增加：蛋白质氧化在自身免疫中的潜在作用。
3. Natural anticoagulant proteins in the regulation of autoimmunity: potential role of protein S. [J] . Anderson HA, Shacter E Current pharmaceutical design . 2004,第8期

机译：天然抗凝蛋白在自身免疫调节中的作用：蛋白S的潜在作用。
4. Top Down 3D Spatial Mapping of Myelin Basic Protein Proteoforms: Organism and Spatial Diversification and its Potential Impact on Autoimmunity [C] . Daniel A. Plymire, John R. Corbett, Casey E. Wing, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：髓鞘碱性蛋白质蛋白质血清的顶部3D空间映射：有机体和空间多样化及其对自身免疫的潜在影响
5. The role of complementary proteins in autoimmune glomerulonephritis. [D] . Pressler, Barrak M. 2008

机译：互补蛋白在自身免疫性肾小球肾炎中的作用。
6. Increased Nitration and Carbonylation of Proteins in MRL +/+ Mice Exposed to Trichloroethene: Potential Role of Protein Oxidation in Autoimmunity [O] . Gangduo Wang, Jianling Wang, Huaxian Ma, -1

机译：在暴露于三氯乙烯的MRL + / +小鼠中提高蛋白质的硝化和羰基化：蛋白质氧化在自身免疫中的潜在作用
7. Increased nitration and carbonylation of proteins in MRL +/+ mice exposed to trichloroethene: Potential role of protein oxidation in autoimmunity [O] . Gangduo Wang, Jianling Wang, Huaxian Ma, 2009

机译：在暴露于三氯乙烯的MRL + / +小鼠中提高蛋白质的硝化和羰基化：蛋白质氧化在自身免疫中的潜在作用

Role of complementary proteins in autoimmunity: an old idea re-emerges with new twists.

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