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首页> 外文期刊>Trends in immunology >Pleiotropic Functions of H3K27Me3 Demethylases in Immune Cell Differentiation
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Pleiotropic Functions of H3K27Me3 Demethylases in Immune Cell Differentiation

机译：H3K27Me3脱甲基酶在免疫细胞分化中的多效性功能。

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摘要

The trimethylation of histone H3 lysine 27 (H3K27Me3) contributes to gene repression, notably through recruitment of Polycomb complexes, and has long been considered essential to maintain cell identity. Whereas H3K27Me3 was thought to be stable and not catalytically reversible, the discovery of the Utx and Jmjd3 demethylases changed this notion, raising new questions on the role of these enzymes in gene expression and cell differentiation. Recent studies have demonstrated critical roles for Utx and Jmjd3 in the development and function of immune cells, and revealed both demethylase and demethylase-independent activities of these enzymes. I review these finding here, and discuss the current understanding of the mechanisms that underlie the broad, yet highly cell- and gene-specific, impact of these enzymes in vivo.
机译：组蛋白H3赖氨酸27（H3K27Me3）的三甲基化特别是通过募集Polycomb复合体来促进基因抑制，长期以来被认为对维持细胞身份至关重要。 H3K27Me3被认为是稳定的并且不是催化可逆的，而Utx和Jmjd3脱甲基酶的发现改变了这一概念，从而对这些酶在基因表达和细胞分化中的作用提出了新的疑问。最近的研究表明，Utx和Jmjd3在免疫细胞的发育和功能中起关键作用，并揭示了这些酶的脱甲基酶和脱甲基酶独立活性。我在这里回顾了这些发现，并讨论了目前对这些酶在体内具有广泛但高度细胞和基因特异性影响的机制的理解。

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