How do DCs interact with intestinal antigens?

Milling SW; Cousins L; Macpherson GG

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How do DCs interact with intestinal antigens?

机译：DC如何与肠道抗原相互作用？

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Recent evidence demonstrates that dendritic cells (DCs) can insert dendrites between the epithelial cells that form the barrier protecting the body from the gut contents. Although first observed almost a decade ago, this is a controversial area of DC biology and the physiological importance of this phenomenon is only now being clarified. A recent study by Niess and colleagues shows that this behaviour enables efficient sampling of both invasive and non-invasive bacteria and might enhance the ability of an organism to resist infections by a pathogenic strain of Salmonella.

机译：最近的证据表明，树突状细胞（DC）可以在树突状细胞之间插入树突状细胞，这些树状细胞形成了保护人体免受肠内容物侵害的屏障。尽管在大约十年前首次发现，但这是DC生物学的一个有争议的领域，这种现象的生理重要性直到现在才得以阐明。 Niess及其同事的最新研究表明，这种行为可以对侵入性和非侵入性细菌进行有效采样，并可能增强生物体抵抗沙门氏菌病原体感染的能力。

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《Trends in immunology》 |2005年第7期|共4页
作者
Milling SW; Cousins L; Macpherson GG;
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正文语种 eng
中图分类医学免疫学;
关键词
Antigens; Sampling; Gut; Bacterial; 抗原;

机译：Antigens;Sampling;Gut;Bacterial;抗原;

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专利

1. How do DCs interact with intestinal antigens? [J] . Milling SW, Cousins L, Macpherson GG Trends in immunology . 2005,第7期

机译：DC如何与肠道抗原相互作用？
2. Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions [J] . Jin Xin, Bu Qingpan, Zou Yingying, Glycoconjugate journal . 2018,第3期

机译：Lewis-altigen的ICAM-2/3对Jurkat白血病细胞与DC标志相互作用以调节DC功能
3. Fission Yeast Cdc24 Is a Replication Factor C- and Proliferating Cell Nuclear Antigen-Interacting Factor Essential for S-Phase Completion [J] . Hiroyuki Tanaka, Koichi Tanaka, Hiroshi Murakami, Molecular and Cellular Biology . 1999,第2期

机译：裂变酵母Cdc24是复制因子C和增殖细胞核抗原相互作用因子，S期完成必不可少。
4. Murine Intestinal Bacteria Modulate Antigen-Specific Cytokine Production by Intestinal Immune Cells Derived from Germ-Free TCR-Transgenic Mice [C] . Masato Tsuda, Akira Hosono, Tsutomu Yanagibashi, Annual Meeting of the Japanese Association for Animal Cell Technology . 2009

机译：小鼠肠道细菌调节衍生自无菌TCR-转基因小鼠的肠免疫细胞的抗原特异性细胞因子产生
5. B lymphocyte antigenic surveillance and immunoregulation in the gut mucosa: Implications for modulation of intestinal inflammation and infectious disease protection. [D] . Velazquez, Peter. 2005

机译：肠粘膜中的B淋巴细胞抗原监视和免疫调节：对肠道炎症调节和传染病保护的意义。
6. Fission Yeast Cdc24 Is a Replication Factor C- and Proliferating Cell Nuclear Antigen-Interacting Factor Essential for S-Phase Completion [O] . Hiroyuki Tanaka, Koichi Tanaka, Hiroshi Murakami, 1999

机译：裂变酵母Cdc24是S期完成必不可少的复制因子C和增殖细胞核抗原相互作用因子。
7. Lymph borne CD8α⁺ DCs are uniquely able to cross-prime CD8⁺ T cells with antigen acquired from intestinal epithelial cells [O] . Cerovic, V, Houston, SA, Utriainen, L, 2014

机译：淋巴传播的CD8α^{+ DCs能够独特地与从肠上皮细胞获得的抗原交叉引发CD8 ^{+ T细胞}}

How do DCs interact with intestinal antigens?

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