Turning a tiger into a house cat: using Legionella pneumophila to study Coxiella burnetii

Joseph P. Vogel

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Turning a tiger into a house cat: using Legionella pneumophila to study Coxiella burnetii

机译：将老虎变成家猫：使用嗜肺军团菌研究伯氏柯氏杆菌

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Understanding how Coxiella burnetii causes Q fever has proven to be exceedingly difficult owing to its obligate intracellular nature. Sequencing the C. burnetii genome revealed the presence of genes that could encode a type IV secretion system highly homologous to the Dot/Icm system in Legionella pneumophila. Recently, two groups have exploited this similarity by expressing the C. burnetii dot/icm homologues in a surrogate host, L. pneumophila, to determine their function.

机译：由于其专心的细胞内性质，了解伯氏柯氏杆菌如何引起Q发热已变得异常困难。伯氏梭菌基因组测序显示，存在可以编码与嗜肺军团菌的Dot / Icm系统高度同源的IV型分泌系统的基因。最近，两个小组通过在替代宿主嗜肺乳杆菌中表达伯氏梭菌斑点/ icm同源物来利用其相似性来确定其功能。

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《Trends in Microbiology》 |2004年第3期|共3页
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Joseph P. Vogel;
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1. Turning a tiger into a house cat: using Legionella pneumophila to study Coxiella burnetii [J] . Joseph P. Vogel Trends in Microbiology . 2004,第3期

机译：将老虎变成家猫：使用嗜肺军团菌研究伯氏柯氏杆菌
2. Low antibodies titer and serological cross-reaction between Coxiella burnetii and Legionella pneumophila challenge the diagnosis of mediastinitis, an emerging Q fever clinical entity [J] . Sophie Edouard, Matthieu Million, Jean-Paul Casalta, Infection . 2017,第6期

机译：低抗体滴度和Coxiella Burnetii和军团骨痛之间的血清学交叉反应挑战纵隔炎患者诊断，是一种新兴Q发烧临床实体
3. The response regulator PmrA is a major regulator of the icm/dot type IV secretion system in Legionella pneumophila and Coxiella burnetii [J] . Zusman T, Aloni G, Halperin E, Molecular Microbiology . 2007,第5期

机译：反应调节物PmrA是嗜肺军团菌和小肠柯氏杆菌中icm /点IV型分泌系统的主要调节剂
4. COXIELLA BURNETII DNA NOT IDENTIFIED IN FLEAS FROM DOMESTIC CATS IN AUSTRALIA AND THE USA [C] . Alison Manchester, Jennifer Hawley, Julia Beatty, Conference of the American^College^of^Veterinary^Internal^Medicine . 2016

机译：Coxiella Burnetii DNA未在澳大利亚和美国的家养猫跳蚤签发
5. The Identification and Characterization of a Novel Clinically Relevant Legionella Species, Legionella cardiaca, and the Role of Three Type II Secreted Effectors in Legionella pneumophila Metabolism, Physiology and Pathogenesis [D] . Pearce, Meghan McGraw 2011

机译：新型临床相关军团菌，军团菌的鉴定和表征，以及三种II型分泌效应物在嗜肺军团菌代谢，生理和发病机理中的作用
6. Specificity of Legionella pneumophila and Coxiella burnetii Vacuoles and Versatility of Legionella pneumophila Revealed by Coinfection [O] . John-Demian Sauer, Jeffrey G. Shannon, Dale Howe, 2005

机译：合并感染揭示了军团菌嗜肺军团菌和伯氏柯氏杆菌的特异性和多功能性
7. Specificity of Legionella pneumophila and Coxiella burnetii Vacuoles and Versatility of Legionella pneumophila Revealed by Coinfection [O] . Sauer, John-Demian, Shannon, Jeffrey G., Howe, Dale, 2005

机译：合并感染揭示了军团菌嗜肺军团菌和伯氏柯氏杆菌的特异性和多功能性
8. 'In vitro' Studies on the Interaction of Rickettsia and Macrophages. I. Effect of Ultraviolet Light on 'Coxiella burnetii' Inactivation and Macrophage Enzymes: UV-Inactivated 'C. burnetii'/Macrophage Enzymes [R] . Little, J. S., Kishimoto, R. A., Canonico, P. G. 1979

机译：立克次体与巨噬细胞相互作用的“体外”研究。 I.紫外线对'Coxiella burnetii'灭活和巨噬细胞酶的影响：紫外线灭活'C. burnetii'/巨噬细胞酶

Turning a tiger into a house cat: using Legionella pneumophila to study Coxiella burnetii

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