• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Trends in Microbiology >Humoral immunity to HIV-1: neutralisation and antibody effector functions
【24h】

Humoral immunity to HIV-1: neutralisation and antibody effector functions

机译：对HIV-1的体液免疫：中和作用和抗体效应子功能

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Several features of HIV have frustrated efforts to develop a vaccine able to induce broadly neutralising antibodies. The enormous genetic diversity of HIV is a major factor, accompanied by the camouflaged nature of the envelope spike, upon which HIV depends for cellular entry and to which antibodies must bind to neutralise. The picture is further complicated by the presence of nonfunctional envelope glycoproteins on the surface of HIV that are immunogenic. Consequently, HIV attracts antibodies that do not directly neutralise the virus but still activate complement and engage Fc receptors, which can both enhance and inhibit infection. The various effects that anti-envelope antibodies have on HIV infection will be reviewed here. Further research is needed to determine if these in vitro-characterised activities have relevance in vivo, and if some of the undesirable effects of non-neutralising antibodies can be avoided or the beneficial effects harnessed.
机译：HIV的几种特征使人们无法开发出能够诱导广泛中和抗体的疫苗。 HIV的巨大遗传多样性是一个主要因素，并伴随着包膜峰的伪装性质，HIV依赖于该包膜进入细胞并且抗体必须结合才能中和。由于具有免疫原性的HIV表面上存在非功能性包膜糖蛋白，使情况更加复杂。因此，HIV吸引的抗体不能直接中和病毒，但仍可以激活补体并与Fc受体结合，从而可以增强和抑制感染。此处将综述抗包膜抗体对HIV感染的各种作用。需要进行进一步的研究以确定这些体外表征的活性在体内是否具有相关性，以及是否可以避免非中和抗体的某些不良作用或利用其有益作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号