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Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus

机译：丙型肝炎病毒重组分子机制的比较分析

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摘要

Genetic recombination is an important evolutionary mechanism for RNA viruses. The significance of this phenomenon for hepatitis C virus (HCV) has recently become evident, with the identification of circulating recombinant forms in HCV-infected individuals and by novel data from studies permitted by advances in HCV cell culture systems and genotyping protocols. HCV is readily able to produce viable recombinants, using replicative and non-replicative molecular mechanisms. However, our knowledge of the required molecular mechanisms remains limited. Understanding how HCV recombines might be instrumental for a better monitoring of global epidemiology, to clarify the virus evolution, and evaluate the impact of recombinant forms on the efficacy of oncoming combination drug therapies. For the latter, frequency and location of recombination events could affect the efficacy of multidrug regimens. This review will focus on current data available on HCV recombination, also in relation to more detailed data from other RNA viruses.C1 Bukh, Jens; Univ Copenhagen, Hvidovre Hosp, Dept Infect Dis, Copenhagen Hepatitis C Program CO HEP, Copenhagen, DenmarkRI Galli, Andrea/F-3084-2011OI Galli, Andrea/0000-0002-4404-430XSC Infectious Diseases; Gastroenterology & Hepatology; Genetics & Heredity
机译：遗传重组是RNA病毒的重要进化机制。随着丙型肝炎病毒（HCV）感染个体中循环重组形式的鉴定以及丙型肝炎病毒细胞培养系统和基因分型规程研究的新数据，这种现象对丙型肝炎病毒（HCV）的重要性近来已变得显而易见。 HCV能够利用复制和非复制分子机制轻易地产生有活力的重组体。但是，我们对所需分子机制的了解仍然有限。了解HCV重组如何有助于更好地监测全球流行病学，阐明病毒进化并评估重组形式对即将到来的联合药物疗法的疗效的影响。对于后者，重组事件的频率和位置可能会影响多药疗法的疗效。这篇综述将侧重于有关HCV重组的现有数据，也涉及其他RNA病毒的更详细数据。哥本哈根大学，Hvidovre医院，部门传染病，哥本哈根丙型肝炎计划CO HEP，哥本哈根，丹麦RI加利，Andrea / F-3084-2011OI加利，Andrea / 0000-0002-4404-430XSC传染病;胃肠病学和肝病学;遗传与遗传

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