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首页> 外文期刊>Tropical Animal Health and Production >Psoroptes cuniculi induced oxidative imbalance in rabbits and its alleviation by using vitamins A, D3, E, and H as adjunctive remedial.
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Psoroptes cuniculi induced oxidative imbalance in rabbits and its alleviation by using vitamins A, D3, E, and H as adjunctive remedial.

机译：Psoropts cuniculi 诱导的​​家兔氧化失衡，并通过补充维生素A，D 3 ，E和H来缓解。

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摘要

The oxidant/antioxidant balance of rabbits naturally infected with Psoroptes cuniculi and treated with ivermectin +/- vitamins A, D3, E, and H supplementation was investigated. Two groups of seven mixed [male] and [female], 6-to-8 month-old New Zealand White rabbits, diagnosed Psoroptes mites-positive by skin scraping examination and seven clinically healthy control rabbits were examined. Blood samples were obtained on day 0 and at 28 days post-therapy to determine oxidative stress indices. On day 0, the levels of lipid peroxides were significantly higher (P<=0.01) in the Psoroptes-infected rabbits compared with the healthy controls while those of reduced glutathione and the activities of the antioxidant enzymes glutathione peroxidase, glutathione-S-transferase, catalase, and superoxide dismutase were significantly lower (P<=0.01). Vitamin supplementation of the ivermectin-treated rabbits revealed both faster clinical (14 days) and parasitological (10 days) recovery. It was concluded that significant alteration of oxidant/antioxidant balance is a factor in the pathogenesis of P. cuniculi infestation of rabbits, and recovery can be enhanced by combining ivermectin treatment with vitamin A, D3, E, and H supplementation.
机译：研究了自然感染 Psoropts cuniculi 并用伊维菌素+/-维生素A，D 3 ，E和H补充处理的兔子的氧化/抗氧化平衡。两组，每只7至6到8个月大的混合[雄性]和[雌性]新西兰大白兔，经刮擦检查诊断为 Psoroptes 螨虫阳性，并检查了7只临床健康的对照兔。在治疗后第0天和第28天获得血样，以确定氧化应激指数。在第0天，感染了 Psoroptes 的兔子的脂质过氧化物水平显着高于健康对照组（ P <= 0.01），而减少了谷胱甘肽和谷胱甘肽的动物体内过氧化物抗氧化酶谷胱甘肽过氧化物酶，谷胱甘肽-S -转移酶，过氧化氢酶和超氧化物歧化酶的活性显着降低（ P <= 0.01）。伊维菌素治疗兔子的维生素补充显示临床恢复更快（14天）和寄生虫学恢复（10天）。结论是，氧化剂/抗氧化剂平衡的显着改变是P发病机理中的一个因素。伊维菌素治疗与维生素A，D 3， E和H的补充相结合，可改善家兔对兔子的侵染，并提高恢复。

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